P-288: Effect of long-term HMG-CoA-reductase inhibitor therapy on large artery endothelial function and distensibility after kidney transplantation

Background: In kidney transplant recipients (RTX) impaired functional arterial vessel wall properties contribute to high cardiovascular morbidity and mortality. Short-term treatment with HMG-CoA reductase inhibitors can improve endothelial function in RTX, however, whether this effect is sustained a...

Full description

Saved in:
Bibliographic Details
Published in:American journal of hypertension 2003-05, Vol.16 (S1), p.141A-141A
Main Authors: Hillebrandt, Uta, Kosch, Markus A., Barenbrock, Michael, Levers, Andrea, Rahn, Karl H., Hausberg, Martin
Format: Article
Language:English
Subjects:
endothelial function
HMG-CoA reductase inhibitor
kidney transplantation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: In kidney transplant recipients (RTX) impaired functional arterial vessel wall properties contribute to high cardiovascular morbidity and mortality. Short-term treatment with HMG-CoA reductase inhibitors can improve endothelial function in RTX, however, whether this effect is sustained and accompanied by improvement of arterial distensibility is not clear. We therefore studied the effects of a long-term therapy with fluvastatin (FLU) on large artery distensibility and brachial artery flow-mediated vasodilation (FMD) as measure of endothelial function in hypercholesterolemic RTX. Methods: 26 RTX with stable graft function randomized to either FLU 40 mg/d (n=13) or Placebo (PLA) (n=13) were followed for three years. At baseline and after 12 and 36 months treatment, carotid and brachial artery distensibility coefficients as well as brachial artery FMD and endothelium-independent nitroglycerin-induced vasodilation (NMD) were measured using high-resolution ultrasound and doppler frequency analysis of vessel wall movements in M-Mode. Data are means±SEM. Results: A significant decrease in total (from 267±9 to 241±9 and 247±11 mg/dl, p
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/S0895-7061(03)00453-9