P-547: The influence of hemodialysis in the VEGF serum levels

Neovascularization is known to occur in human atherosclerotic plaques. Vascular endothelial growth factor (VEGF) is an important angiogenic factor that could play a role in atherogenesis. The goal of our study was to evaluate the influence of hemodialysis (HD) on serum levels of the above factor and...

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Published in:American journal of hypertension 2004-05, Vol.17 (S1), p.232A-233A
Main Authors: Soubassi, Lygeri P., Chaniotis, Dimitrios I., Kotsis, Vassilios, Soubassi, Sofia P., Zerefos, Stylianos N., Sarandakou, Angeliki, Lekakis, Ioannis P., Mavrikakis, Myron M., Valis, Dimitrios N., Soubassis, Pavlos T., Zerefos, Nikolaos S.
Format: Article
Language:English
Subjects:
Angiogenesis
Chronic Renal Failure
Hemodialysis
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Summary:Neovascularization is known to occur in human atherosclerotic plaques. Vascular endothelial growth factor (VEGF) is an important angiogenic factor that could play a role in atherogenesis. The goal of our study was to evaluate the influence of hemodialysis (HD) on serum levels of the above factor and its probable contribution to the development of coronary artery disease (CAD). The study population consisted of 58 patients (pts) with mean age 59 ± 11 (35M and 23F) on chronic HD for 50.4 ± 44.4 months and body mass index 24 ± 4. They were compared to 40 healthy age-matched controls (HC). Patients with autoimmune diseases, diabetes mellitus and malignant diseases were excluded. Serum levels of VEGF were measured before HD using a quantitative sandwich enzyme immunoarray technique (Quantikinine®). Serum total cholesterol, triglycerides, parathormone, Ca × P, BUN, creatinine, albumin, hematocrit, were also measured at the same time. The results of VEGF measurements are shown in the Table. Factor HC HD P VEGF (pg/mL) 127 ± 68 581 ± 333 0.0001 A negative correlation was also observed between VEGF and calcium (r=−0.28, p=0.03) and between VEGF and BMI (r=−0.25, p=0.05). There was no correlation between this marker and age, sex, duration of HD, membrane type, TC, TG, PTH, phosphorus, BUN, creatinine, and albumin. Serum VEGF levels are significantly elevated in pts undergoing HD compared to HC. The mechanism (s) and significance of VEGF elevation and its probable contribution to atherosclerosis in HD pts should be thoroughly investigated.
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/j.amjhyper.2004.03.621