Ion homeostasis, energy substrates, and network activity in developing brain

During the last two decades, it has become widely accepted that GABA, the main inhibitory neurotransmitter in mammalian nervous system, exhibits excitatory action at the early stages of postnatal development. This results from a high intracellular Cl − concentration at these stages of the developmen...

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Bibliographic Details
Published in:Biochemistry (Moscow). Supplement series A, Membrane and cell biology Membrane and cell biology, 2012-04, Vol.6 (2), p.139-145
Main Authors: Bregestovski, P., Zilberter, Yu
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Brain
Cell Biology
Homeostasis
Ions
Life Sciences
Neurotransmitters
Reviews
Substrates
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Summary:During the last two decades, it has become widely accepted that GABA, the main inhibitory neurotransmitter in mammalian nervous system, exhibits excitatory action at the early stages of postnatal development. This results from a high intracellular Cl − concentration at these stages of the development and is associated with spontaneous synchronized network discharges known as Giant Depolarizing Potentials (GDPs). It has been hypothesized that the excitatory action of GABAergic system stimulates synaptogenesis and the development of neuronal networks. However, accumulating recent observations challenge this view. Here we present a brief review of the current concepts and problems they face in the light of new data.
ISSN:1990-7478
1990-7494
DOI:10.1134/S1990747812010035