Localization of epidermal-type fatty acid binding protein in alveolar macrophages and some alveolar type II epithelial cells in mouse lung

Almost all alveolar macrophages in the mouse lung were strongly immunoreactive for epidermal-type fatty acid binding protein. At the electron microscope level, the immunoreactive material was localized diffusely in the cytoplasm but not within the nucleus. A certain number of alveolar type II epithe...

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Bibliographic Details
Published in:Journal of molecular histology 2001-08, Vol.33 (8), p.453-457
Main Authors: Owada, Y, Abdelwahab, S A, Suzuki, R, Iwasa, H, Sakagami, H, Spener, F, Kondo, H
Format: Article
Language:English
Subjects:
Animals
Blotting, Northern
Carrier Proteins - genetics
Carrier Proteins - metabolism
Epidermis - chemistry
Fatty Acid-Binding Protein 7
Fatty Acid-Binding Proteins
Female
Lung - chemistry
Lungs
Macrophages, Alveolar - metabolism
Macrophages, Alveolar - ultrastructure
Male
Mice
Mice, Inbred BALB C
Microscopy, Immunoelectron
Neoplasm Proteins
Nerve Tissue Proteins
Proteins
Pulmonary Alveoli - metabolism
Pulmonary Alveoli - ultrastructure
RNA, Messenger - metabolism
Rodents
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Summary:Almost all alveolar macrophages in the mouse lung were strongly immunoreactive for epidermal-type fatty acid binding protein. At the electron microscope level, the immunoreactive material was localized diffusely in the cytoplasm but not within the nucleus. A certain number of alveolar type II epithelial cells were also immunoreactive for the protein with variable immunointensity, while a substantial number of the type II cells were immunonegative. No immunoreactive interstitial fibroblasts were encountered. Based on the present findings, possible roles of epidermal-type fatty acid binding protein in the host-defence mechanism played by alveolar macrophages are suggested.
ISSN:0018-2214
1567-2379
1573-6865
1567-2387
DOI:10.1023/A:1014420330284