Staging and Functional Characterization of Pheochromocytoma and Paraganglioma by ^sup 18^F-Fluorodeoxyglucose (^sup 18^F-FDG) Positron Emission Tomography

Pheochromocytomas and paragangliomas (PPGLs) are rare tumors of the adrenal medulla and extra-adrenal sympathetic chromaffin tissues; their anatomical and functional imaging are critical to guiding treatment decisions. Henri et al compare the sensitivity and specificity of ^sup 18^F-fluorodeoxygluco...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2012-05, Vol.104 (9), p.700
Main Authors: Timmers, Henri J L M, Chen, Clara C, Carrasquillo, Jorge A, Whatley, Millie, Ling, Alexander, Eisenhofer, Graeme, King, Kathryn S, Rao, Jyotsna U, Wesley, Robert A, Adams, Karen T, Pacak, Karel
Format: Article
Language:English
Subjects:
Medical diagnosis
Oncology
Tomography
Tumors
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Summary:Pheochromocytomas and paragangliomas (PPGLs) are rare tumors of the adrenal medulla and extra-adrenal sympathetic chromaffin tissues; their anatomical and functional imaging are critical to guiding treatment decisions. Henri et al compare the sensitivity and specificity of ^sup 18^F-fluorodeoxyglucose positron emission tomography with computed tomography (^sup 18^F-FDG PET/CT) for tumor localization and staging of PPGLs with that of conventional imaging by [^sup 123^I]-metaiodobenzylguanidine single photon emission CT (^sup 123^I-MIBG SPECT), CT, and magnetic resonance imaging (MRI). Results suggest that compared with ^sup 123^I-MIBG SPECT and CT/MRI, both considered gold standards for PPGL imaging, metastases were better detected by ^sup 18^F-FDG PET. ^sup 18^F-FDG PET provides a high specificity in patients with a biochemically established diagnosis of PPGL.
ISSN:0027-8874
1460-2105