Impact of Malaria on Genetic Polymorphism and Genetic Diseases in Africans and African Americans

The high mortality from malaria in sub-Sahara Africa selected multiple genes that give the population a selective advantage. Identification of the genetic basis for resistance may suggest unusual approaches to development of malarial vaccines and antimalarial drugs. Some of these genes may be delete...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1994-03, Vol.91 (7), p.2415-2419
Main Author: Miller, Louis H.
Format: Article
Language:English
Subjects:
Africa South of the Sahara - ethnology
African Americans
African Continental Ancestry Group - genetics
Antigens
Biological and medical sciences
Black people
Blood Group Antigens - genetics
Erythrocytes
Genes
Hemoglobins
HLA Antigens - genetics
Human protozoal diseases
Humans
Hypertension
Hypertension - genetics
Infectious diseases
Liver Diseases - genetics
Malaria
Malaria - complications
Malaria - ethnology
Malaria - mortality
Medical research
Medical sciences
Metabolic Diseases - complications
Metabolic Diseases - genetics
Mortality
Parasites
Parasitic diseases
Polymorphism, Genetic
Protozoal diseases
Receptors
T lymphocytes
United States
Vaccines
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Summary:The high mortality from malaria in sub-Sahara Africa selected multiple genes that give the population a selective advantage. Identification of the genetic basis for resistance may suggest unusual approaches to development of malarial vaccines and antimalarial drugs. Some of these genes may be deleterious, although of selective advantage within the African setting, and need to be identified for counseling for disease prevention.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.91.7.2415