Amino Acid and cDNA Sequences of a Vascular Endothelial Cell Mitogen that is Homologous to Platelet-Derived Growth Factor

Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1990-04, Vol.87 (7), p.2628-2632
Main Authors: Conn, Greg, Bayne, Marvin L., Soderman, Denis D., Kwok, Perry W., Sullivan, Kathleen A., Plisi, Thomas M., Hope, Debra A., Thomas, Kenneth A.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Analytical, structural and metabolic biochemistry
Animals
Base Sequence
Biological and medical sciences
Cell growth
Cloning, Molecular
Complementary DNA
DNA - genetics
Endothelial cells
Endothelial growth factors
Endothelium, Vascular - metabolism
Exons
Fibroblast growth factors
Fundamental and applied biological sciences. Psychology
Glycoproteins - genetics
Glycoproteins - isolation & purification
Growth Substances - genetics
Growth Substances - isolation & purification
Humans
Macromolecular Substances
Mitogens
Molecular Sequence Data
Oligonucleotide Probes
Platelet-Derived Growth Factor - genetics
Polymerase Chain Reaction
Protein hormones. Growth factors. Cytokines
Proteins
Rats
Sequence Homology, Nucleic Acid
Sequencing
Vascular Endothelial Growth Factor A
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Description
Summary:Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an aminoterminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.87.7.2628