Human Antigen and Enzyme Markers in Man-Chinese Hamster Somatic Cell Hybrids: Evidence for Synteny between the HL-A, PGM3, ME1, and IPO-B Loci

In man-Chinese hamster somatic cell hybrids the segregation of the loci for 27 human enzyme markers and the species-specific surface antigens, including the HL-A histocompatibility antigens, was studied. The results show a synteny of the human loci for phosphoglucomutase 3, cytoplasmic malic enzyme,...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1974-03, Vol.71 (3), p.962-965
Main Authors: Van Someren, H., Westerveld, A., Hagemeijer, A., Mees, J. R., Khan, P. Meera, Zaalberg, O. B.
Format: Article
Language:English
Subjects:
Animals
Antigens
Antigens - analysis
Biological Sciences: Genetics
Cell Line
Cell lines
Chromosome Mapping
Chromosomes
Cricetinae
Cytotoxicity Tests, Immunologic
Electron Transport Complex IV - biosynthesis
Enzymes
Fibroblasts
Genes
Genetic Linkage
Genetic loci
HeLa Cells - immunology
Histocompatibility Antigens
Humans
Hybrid cells
Hybrid Cells - enzymology
Hybridity
Immune Adherence Reaction
Leukocytes
Malate Dehydrogenase - biosynthesis
Phosphoglucomutase - biosynthesis
Skin
Somatic cells
Species Specificity
Synteny
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Summary:In man-Chinese hamster somatic cell hybrids the segregation of the loci for 27 human enzyme markers and the species-specific surface antigens, including the HL-A histocompatibility antigens, was studied. The results show a synteny of the human loci for phosphoglucomutase 3, cytoplasmic malic enzyme, tetrameric indophenol oxidase, and HL-A. Furthermore, evidence is presented that the loci for the human species-specific antigens are distributed over several chromosomes.
ISSN:0027-8424
1091-6490