Childhood infection burden, recent antibiotic exposure and vascular phenotypes in preschool children

Severe childhood infection has a dose-dependent association with adult cardiovascular events and with adverse cardiometabolic phenotypes. The relationship between cardiovascular outcomes and less severe childhood infections is unclear. To investigate the relationship between common, non-hospitalised...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2023-09, Vol.18 (9), p.e0290633-e0290633
Main Authors: Yu, Angela, Jansen, Maria A. C, Dalmeijer, Geertje W, Bruijning-Verhagen, Patricia, van der Ent, Cornelis K, Grobbee, Diederick E, Burgner, David P, Uiterwaal, Cuno S. P. M
Format: Article
Language:English
Subjects:
Adults
Analysis
Antibiotics
Atherosclerosis
Biology and Life Sciences
Birth weight
Blood pressure
Body mass
Body mass index
Body size
Cardiovascular diseases
Care and treatment
Carotid arteries
Carotid artery
Children
Children & youth
Codes
Cohort analysis
Complications and side effects
Confidence intervals
Diagnosis
Disease prevention
Exposure
Genetic aspects
Gestational age
Health aspects
Illnesses
Infection
Infections
Infectious diseases
Medical research
Medicine and Health Sciences
Medicine, Experimental
Parents
Patient outcomes
Pediatrics
Phenotype
Phenotypes
Physical Sciences
Population studies
Preschool children
Questionnaires
Regression analysis
Regression models
Research and Analysis Methods
Risk factors
Socioeconomic factors
Socioeconomics
Statistical analysis
Variables
Variance analysis
Wheezing
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Severe childhood infection has a dose-dependent association with adult cardiovascular events and with adverse cardiometabolic phenotypes. The relationship between cardiovascular outcomes and less severe childhood infections is unclear. To investigate the relationship between common, non-hospitalised infections, antibiotic exposure, and preclinical vascular phenotypes in young children. A Dutch prospective population-derived birth cohort study. Recent antibiotic exposure was associated with adverse cardiovascular phenotypes; each antibiotic prescription in the 3 and 6 months prior to vascular assessment was associated with an 18.1 [mu]m (95% confidence interval, 4.5-31.6, p = 0.01) and 10.7 [mu]m (0.8-20.5, p = 0.03) increase in CIMT, respectively. Each additional antibiotic prescription in the preceding 6 months was associated with an 8.3 mPa.sup.-1 decrease in carotid distensibility (-15.6- -1.1, p = 0.02). Any parent-reported febrile episode (compared to none) showed weak evidence of association with diastolic BP (1.6 mmHg increase, 0.04-3.1, p = 0.04). GP-diagnosed infections were not associated with vascular phenotypes. Recent antibiotics are associated with adverse vascular phenotypes in early childhood. Mechanistic studies may differentiate antibiotic-related from infection-related effects and inform preventative strategies.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0290633