Isoniazid preventive therapy completion and factors associated with non-completion among patients on antiretroviral therapy at Kisenyi Health Centre IV, Kampala, Uganda

Isoniazid preventive therapy (IPT) is given to HIV patients to reduce the risk of active tuberculosis (TB). However, treatment completion remains suboptimal among those that are initiated. This study aimed to determine the completion level of IPT and the factors associated with non-completion among...

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Bibliographic Details
Published in:PloS one 2023-08, Vol.18 (8), p.e0277739-e0277739
Main Authors: Amanya, Ian, Muhoozi, Michael, Aruhomukama, Dickson, Ssebagereka, Anthony, Mugambe, Richard
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Analysis
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiviral agents
Biology and Life Sciences
Body mass index
Care and treatment
Complications and side effects
Data collection
Diagnosis
Drug therapy
Education
Electronic health records
Females
Health care facilities
Health facilities
Health risks
Highly active antiretroviral therapy
HIV
HIV (Viruses)
HIV patients
Human immunodeficiency virus
Independent variables
Infections
Interviews
Isoniazid
Males
Marital status
Medical records
Medicine and Health Sciences
Medicine, Preventive
Multivariate analysis
Patient outcomes
Patients
People and Places
Preventive health services
Relocation
Risk reduction
Robustness (mathematics)
Therapy
Tuberculosis
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Summary:Isoniazid preventive therapy (IPT) is given to HIV patients to reduce the risk of active tuberculosis (TB). However, treatment completion remains suboptimal among those that are initiated. This study aimed to determine the completion level of IPT and the factors associated with non-completion among patients on antiretroviral therapy (ART) at Kisenyi Health Center IV in Kampala, Uganda. A mixed-methods facility-based retrospective cohort study utilizing routinely collected data from 341 randomly selected HIV patients initiated on IPT was conducted. Data extracted from the registers was used to determine IPT completion. Robust Poisson regression was conducted to determine the associated factors of IPT non-completion, while in-depth interviews were conducted to explore barriers to IPT completion from the patient's perspective. A total of 341 patients who started on isoniazid (INH) were retrospectively followed up, with 69% (236/341) being female. Overall IPT completion was 83%. Multivariate analysis revealed the prevalence of IPT non-completion among males was 2.24 times the prevalence among females (aPR 2.24, 95% CI: 1.40-3.58, p = 0.001). The prevalence of IPT non-completion among patients with a non-suppressed HIV viral load was 3.00 times the prevalence among those with a suppressed HIV viral load (aPR 3.00, 95% CI: 1.44-6.65, p = 0.007). The prevalence of IPT non-completion among patients who were married, or cohabiting was 0.31 times the prevalence among those who were single (aPR 0.31, 95% CI: 0.17-0.55, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0277739