Outcomes of minimal change disease without nephrotic range proteinuria

Minimal change disease (MCD) is characterized by edema and nephrotic range proteinuria (NS). However, the fate of MCD without nephrotic proteinuria requires elucidation. We retrospectively reviewed 79 adults diagnosed with primary MCD at their initial renal biopsy at a tertiary hospital between May...

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Bibliographic Details
Published in:PloS one 2023-08, Vol.18 (8), p.e0289870-e0289870
Main Authors: Son, Hyung Eun, Yun, Giae, Kwon, Eun-Jeong, Park, Seokwoo, Jeong, Jong Cheol, Kim, Sejoong, Na, Ki Young, Paik, Jin Ho, Chin, Ho Jun
Format: Article
Language:English
Subjects:
Adults
Biology and Life Sciences
Biopsy
Blood pressure
Cardiovascular disease
Chronic kidney failure
Complications and side effects
Creatinine
Diagnosis
Edema
Electronic health records
End-stage renal disease
Glomerular filtration rate
Health aspects
Hypertension
Kidney diseases
Lupus
Medical prognosis
Medicine and Health Sciences
Microscopy
Mortality
Pathology
Patients
Physical Sciences
Proteinuria
Remission
Remission (Medicine)
Research and Analysis Methods
Steroid hormones
Steroids
Tertiary
Urine
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Summary:Minimal change disease (MCD) is characterized by edema and nephrotic range proteinuria (NS). However, the fate of MCD without nephrotic proteinuria requires elucidation. We retrospectively reviewed 79 adults diagnosed with primary MCD at their initial renal biopsy at a tertiary hospital between May 2003 and June 2017. Clinicopathologic features were compared between patients with and without NS. The frequency of flaring to nephrotic proteinuria and renal outcomes were assessed during follow-up. There were 20 and 59 patients in the Non-NS and NS groups, respectively. The Non-NS group had a lower frequency of acute kidney injury (AKI) during the follow-up period [5.0% vs. 59.3%, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0289870