Less demand on stem cell marker-positive cancer cells may characterize metastasis of colon cancer

CD44 and CD133 are stem cell markers in colorectal cancer (CRC). CD44 has distinctive isoforms with different oncological properties like total CD44 (CD44T) and variant CD44 (CD44V). Clinical significance of such markers remains elusive. Sixty colon cancer were examined for CD44T/CD44V and CD133 at...

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Bibliographic Details
Published in:PloS one 2023-04, Vol.18 (4), p.e0277395-e0277395
Main Authors: Kaida, Takeshi, Fujiyama, Yoshiki, Soeno, Takafumi, Yokota, Mitsuo, Nakamoto, Shuji, Goto, Takuya, Watanabe, Akiko, Okuno, Kota, Nie, Yusuke, Fujino, Shiori, Yokota, Kazuko, Harada, Hiroki, Tanaka, Yoko, Tanaka, Toshimichi, Yokoi, Keigo, Kojo, Ken, Miura, Hirohisa, Yamanashi, Takahiro, Sato, Takeo, Sasaki, Jiichiro, Sangai, Takafumi, Hiki, Naoki, Kumamoto, Yusuke, Naitoh, Takeshi, Yamashita, Keishi
Format: Article
Language:English
Subjects:
AC133 Antigen - genetics
AC133 Antigen - metabolism
Analysis
Biological markers
Biology and Life Sciences
Biomarkers
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cancer cells
Care and treatment
CD44 antigen
Colon
Colon cancer
Colonic Neoplasms - pathology
Colorectal cancer
Colorectal carcinoma
Consent
Development and progression
Gastrointestinal diseases
Gene amplification
Gene expression
Genetic aspects
Humans
Hyaluronan Receptors - genetics
Hyaluronan Receptors - metabolism
Isoforms
Kinases
Liver
Liver cancer
Liver Neoplasms - pathology
Lymph nodes
Medical colleges
Medicine and Health Sciences
Metastases
Metastasis
Mutation
Neoplastic Stem Cells - metabolism
Phenotypes
Prevention
Protein Isoforms - genetics
Research and Analysis Methods
Risk factors
RNA
RNA, Messenger - genetics
RNA, Messenger - metabolism
Stem cells
Surgery
Thermal cycling
Tumors
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Summary:CD44 and CD133 are stem cell markers in colorectal cancer (CRC). CD44 has distinctive isoforms with different oncological properties like total CD44 (CD44T) and variant CD44 (CD44V). Clinical significance of such markers remains elusive. Sixty colon cancer were examined for CD44T/CD44V and CD133 at mRNA level in a quantitative PCR, and clarified for their association with clinicopathological factors. (1) Both CD44T and CD44V showed higher expression in primary colon tumors than in non-cancerous mucosas (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0277395