COVID-19, maternal, and neonatal outcomes: National Mother-Child Cohort (NMCC) of K-COV-N cohort in South Korea

Throughout the COVID-19 pandemic, pregnant women have been classified as a vulnerable population. However, the evidence on the effect of infection during pregnancy on maternal and neonatal outcomes is still uncertain, and related research comprising a large population of pregnant women in Asian coun...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2023-04, Vol.18 (4), p.e0284779-e0284779
Main Authors: Oh, Jongmin, Lee, Whanhee, Kim, Choong-Jong, Kim, Yi Jun, Park, Hyesook, Lee, Ji Hyen, Park, Mi Hye, Lee, Seulbi, Ha, Eunhee, Lee, Kyung A
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Body mass index
Citizenship
Confidence intervals
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 vaccines
Diabetes
Disease control
Employment
Epidemics
Evaluation
Female
Foreign residents
Gestational age
Health risks
Hemorrhage
Hospitals
Humans
Immunization
Infant, Newborn
Infections
Investigations
Maternal health services
Medical care
Medicine and Health Sciences
Mother-Child Relations
Mothers
Multiple births
National health insurance
Neonatal intensive care
Neonates
Newborn babies
Pandemics
People and Places
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Pregnancy Outcome - epidemiology
Premature birth
Public health
Quality management
Respiratory diseases
Retrospective Studies
Statistical analysis
Variables
Viral diseases
Viral infections
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Throughout the COVID-19 pandemic, pregnant women have been classified as a vulnerable population. However, the evidence on the effect of infection during pregnancy on maternal and neonatal outcomes is still uncertain, and related research comprising a large population of pregnant women in Asian countries is limited. We constructed a national cohort including mothers and children (369,887 pairs) registered in the Prevention Agency-COVID-19-National Health Insurance Service (COV-N), from January 1, 2020 to March 31, 2022. We performed propensity score matchings and generalized estimation equation models to estimate the effect of COVID-19 on maternal and neonatal outcomes. In summary, we found little evidence of the effect of COVID-19 infection during pregnancy on maternal and neonatal outcomes; however, a relationship between COVID-19 infection in the second trimester and postpartum hemorrhages was discovered (Odds ratio (OR) of Delta period: 2.26, 95% Confidence intervals (CI): 1.26, 4.05). In addition, neonatal intensive care unit (NICU) admissions increased due to COVID-19 infection (pre-Delta period: 2.31, 95% CI: 1.31, 4.10; Delta period: 1.99, 95% CI: 1.47, 2.69; Omicron period: 2.36, 95% CI: 1.75, 3.18). Based on the national retrospective cohort study data, this study investigated the effects of COVID-19 infection on maternal and neonatal outcomes in Korea from the pre-Delta to the initial Omicron epidemic periods. Our evidence suggests that the timely and successful policies of the government and academia in response to COVID-19 infections in newborns in Korea may cause an increase in NICU admissions, but nonetheless, they prevent adverse maternal and neonatal outcomes simultaneously.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0284779