Impact of adverse events during community-wide mass drug administration for soil-transmitted helminths on subsequent participation-a Theory of Planned Behaviour analysis

Experiencing adverse events (AEs) during mass drug administration (MDA) could affect participation in future MDAs. This study aims to understand the potential influence of AEs during a community-wide MDA (cMDA) trial for soil-transmitted helminths (STH) in India on intention to participate in future...

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Published in:PLoS neglected tropical diseases 2023-03, Vol.17 (3), p.e0011148-e0011148
Main Authors: Aruldas, Kumudha, Israel, Gideon John, Johnson, Jabaselvi, Titus, Angelin, Saxena, Malvika, Kaliappan, Saravanakumar Puthupalayam, Ramesh, Rohan Michael, Walson, Judd L, Means, Arianna Rubin, Ajjampur, Sitara S R
Format: Article
Language:English
Subjects:
Adverse events
Analysis
Animals
Attitudes
Biology and Life Sciences
Caregivers
Chi-square test
Child
Community
Data analysis
Data collection
Drug therapy
Drugs
Evaluation
Helminthiasis
Helminthiasis - drug therapy
Helminths
Households
Humans
Intervention
Interviews
Likert scale
Mass Drug Administration - methods
Medicine and Health Sciences
Participation
Patient outcomes
People and Places
Public health administration
Questionnaires
Social Sciences
Soil - parasitology
Soils
Theory of Planned Behavior
Tropical diseases
Variables
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Summary:Experiencing adverse events (AEs) during mass drug administration (MDA) could affect participation in future MDAs. This study aims to understand the potential influence of AEs during a community-wide MDA (cMDA) trial for soil-transmitted helminths (STH) in India on intention to participate in future cMDAs. This study was conducted using a multi-method quantitative and qualitative approach among 74 participants who experienced an AE during STH cMDA and the 12 participants who subsequently refused cMDA treatment of the ongoing DeWorm3 trial. Path analysis and thematic analysis guided by the Theory of Planned Behaviour, was used. Among 74 individuals who reported an AE, 12% refused treatment in the cMDA immediately subsequent to their AE and 4% refused in all subsequent cMDAs. Of these 74 individuals, 59 (80%) completed a survey and eight participated in in-depth interviews. A positive attitude towards deworming and perceived ability to participate in cMDA (perceived behavioural control) were significant predictors of intention to participate in cMDA (p
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0011148