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Induction of flight via midbrain projections to the cuneiform nucleus
The dorsal periaqueductal gray is a midbrain structure implicated in the control of defensive behaviors and the processing of painful stimuli. Electrical stimulation or optogenetic activation of excitatory neurons in dorsal periaqueductal gray results in freezing or flight behavior at low and high i...
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Published in: | PloS one 2023-02, Vol.18 (2), p.e0281464-e0281464 |
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description | The dorsal periaqueductal gray is a midbrain structure implicated in the control of defensive behaviors and the processing of painful stimuli. Electrical stimulation or optogenetic activation of excitatory neurons in dorsal periaqueductal gray results in freezing or flight behavior at low and high intensity, respectively. However, the output structures that mediate these defensive behaviors remain unconfirmed. Here we carried out a targeted classification of neuron types in dorsal periaqueductal gray using multiplex in situ sequencing and then applied cell-type and projection-specific optogenetic stimulation to identify projections from dorsal periaqueductal grey to the cuneiform nucleus that promoted goal-directed flight behavior. These data confirmed that descending outputs from dorsal periaqueductal gray serve as a trigger for directed escape behavior. |
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Electrical stimulation or optogenetic activation of excitatory neurons in dorsal periaqueductal gray results in freezing or flight behavior at low and high intensity, respectively. However, the output structures that mediate these defensive behaviors remain unconfirmed. Here we carried out a targeted classification of neuron types in dorsal periaqueductal gray using multiplex in situ sequencing and then applied cell-type and projection-specific optogenetic stimulation to identify projections from dorsal periaqueductal grey to the cuneiform nucleus that promoted goal-directed flight behavior. These data confirmed that descending outputs from dorsal periaqueductal gray serve as a trigger for directed escape behavior.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0281464</identifier><identifier>PMID: 36795666</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biology and Life Sciences ; Defensive behavior ; Electric Stimulation ; Electrical stimuli ; Escape behavior ; Flight ; Flight behavior ; Freezing ; Gene expression ; Laboratories ; Localization ; Medicine and Health Sciences ; Mesencephalon ; Midbrain Reticular Formation ; Neurons ; Neurons - physiology ; Periaqueductal Gray ; Periaqueductal gray area ; Quality control ; Rats ; Rats, Wistar ; Research and Analysis Methods ; Social Sciences ; Stimulation ; Viruses</subject><ispartof>PloS one, 2023-02, Vol.18 (2), p.e0281464-e0281464</ispartof><rights>Copyright: © 2023 Tsang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>2023 Tsang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 Tsang et al 2023 Tsang et al</rights><rights>2023 Tsang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Electrical stimulation or optogenetic activation of excitatory neurons in dorsal periaqueductal gray results in freezing or flight behavior at low and high intensity, respectively. However, the output structures that mediate these defensive behaviors remain unconfirmed. Here we carried out a targeted classification of neuron types in dorsal periaqueductal gray using multiplex in situ sequencing and then applied cell-type and projection-specific optogenetic stimulation to identify projections from dorsal periaqueductal grey to the cuneiform nucleus that promoted goal-directed flight behavior. These data confirmed that descending outputs from dorsal periaqueductal gray serve as a trigger for directed escape behavior.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36795666</pmid><doi>10.1371/journal.pone.0281464</doi><orcidid>https://orcid.org/0000-0001-9129-1322</orcidid><orcidid>https://orcid.org/0000-0002-6743-5266</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Animals Biology and Life Sciences Defensive behavior Electric Stimulation Electrical stimuli Escape behavior Flight Flight behavior Freezing Gene expression Laboratories Localization Medicine and Health Sciences Mesencephalon Midbrain Reticular Formation Neurons Neurons - physiology Periaqueductal Gray Periaqueductal gray area Quality control Rats Rats, Wistar Research and Analysis Methods Social Sciences Stimulation Viruses |
title | Induction of flight via midbrain projections to the cuneiform nucleus |
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