Induction of flight via midbrain projections to the cuneiform nucleus

The dorsal periaqueductal gray is a midbrain structure implicated in the control of defensive behaviors and the processing of painful stimuli. Electrical stimulation or optogenetic activation of excitatory neurons in dorsal periaqueductal gray results in freezing or flight behavior at low and high i...

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Bibliographic Details
Published in:PloS one 2023-02, Vol.18 (2), p.e0281464-e0281464
Main Authors: Tsang, Emmy, Orlandini, Camilla, Sureka, Rahul, Crevenna, Alvaro H, Perlas, Emerald, Prankerd, Izzie, Masferrer, Maria E, Gross, Cornelius T
Format: Article
Language:English
Subjects:
Animals
Biology and Life Sciences
Defensive behavior
Electric Stimulation
Electrical stimuli
Escape behavior
Flight
Flight behavior
Freezing
Gene expression
Laboratories
Localization
Medicine and Health Sciences
Mesencephalon
Midbrain Reticular Formation
Neurons
Neurons - physiology
Periaqueductal Gray
Periaqueductal gray area
Quality control
Rats
Rats, Wistar
Research and Analysis Methods
Social Sciences
Stimulation
Viruses
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Summary:The dorsal periaqueductal gray is a midbrain structure implicated in the control of defensive behaviors and the processing of painful stimuli. Electrical stimulation or optogenetic activation of excitatory neurons in dorsal periaqueductal gray results in freezing or flight behavior at low and high intensity, respectively. However, the output structures that mediate these defensive behaviors remain unconfirmed. Here we carried out a targeted classification of neuron types in dorsal periaqueductal gray using multiplex in situ sequencing and then applied cell-type and projection-specific optogenetic stimulation to identify projections from dorsal periaqueductal grey to the cuneiform nucleus that promoted goal-directed flight behavior. These data confirmed that descending outputs from dorsal periaqueductal gray serve as a trigger for directed escape behavior.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0281464