Mimicking seasonal changes in light-dark cycle and ambient temperature modulates gut microbiome in mice under the same dietary regimen

To better adapt to seasonal environmental changes, physiological processes and behaviors are regulated seasonally. The gut microbiome interacts with the physiology, behavior, and even the diseases of host animals, including humans and livestock. Seasonal changes in gut microbiome composition have be...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2023-02, Vol.18 (2), p.e0278013-e0278013
Main Authors: Matsumoto, Shoko, Ren, Liang, Iigo, Masayuki, Murai, Atsushi, Yoshimura, Takashi
Format: Article
Language:English
Subjects:
Ambient temperature
Analysis
Animal behavior
Animal diseases
Animal experimentation
Animals
Biological clocks
Biology and Life Sciences
Cecum
Circadian rhythm
Composition
Day length
Daylength
Diet
Digestive system
Digestive tract
Environmental aspects
Environmental changes
Evaluation
Females
Gastrointestinal Microbiome - genetics
Genes
Health aspects
Humans
Immune system
Intestinal microflora
Intestine
Laboratory animals
Large intestine
Livestock
Medicine and Health Sciences
Melatonin
Metabolic pathways
Mice
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Mimicry
Photoperiod
Phylogeny
Physiology
Regulatory mechanisms (biology)
Research and Analysis Methods
RNA
RNA, Ribosomal, 16S - genetics
rRNA 16S
Scientific equipment and supplies industry
Seasonal variations
Seasons
Summer
Temperature
Temperature effects
Thermal properties
Winter
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To better adapt to seasonal environmental changes, physiological processes and behaviors are regulated seasonally. The gut microbiome interacts with the physiology, behavior, and even the diseases of host animals, including humans and livestock. Seasonal changes in gut microbiome composition have been reported in several species under natural environments. Dietary content significantly affects the composition of the microbiome, and, in the natural environment, the diet varies between different seasons. Therefore, understanding the seasonal regulatory mechanisms of the gut microbiome is important for understanding the seasonal adaptation strategies of animals. Herein, we examined the effects of changing day length and temperature, which mimic summer and winter conditions, on the gut microbiome of laboratory mice. Principal coordinate analysis and analysis of the composition of microbiomes of 16S rRNA sequencing data demonstrated that the microbiomes of the cecum and large intestine showed significant differences between summer and winter mimicking conditions. Similar to previous studies, a daily rhythm was observed in the composition of the microbiome. Furthermore, the phylogenetic investigation of communities by reconstruction of unobserved states predicted seasonal changes in several metabolic pathways. Changing day length and temperature can affect the composition of the gut microbiome without changing dietary contents.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0278013