Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm

To determine the impact of microvascular invasion (MVI) on outcome in patients with solitary hepatocellular carcinoma (HCC) of ≤ 2 cm undergoing liver resection (LR). This retrospective study enrolled consecutive patients between 2007-2019 with newly diagnosed solitary HCC ≤ 2 cm who were undergoing...

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Bibliographic Details
Published in:PloS one 2023-02, Vol.18 (2), p.e0281154-e0281154
Main Authors: Li, Wei-Feng, Liu, Yueh-Wei, Wang, Chih-Chi, Yong, Chee-Chien, Lin, Chih-Che, Yen, Yi-Hao
Format: Article
Language:English
Subjects:
Antiviral drugs
Biology and Life Sciences
Carcinoma, Hepatocellular - pathology
Care and treatment
Comparative analysis
Creatinine
Deoxyribonucleic acid
DNA
Evaluation
Hepatectomy
Hepatitis B
Hepatitis C
Hepatocellular carcinoma
Hepatoma
Humans
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Liver Neoplasms - pathology
Medical prognosis
Medical records
Medical research
Medicine and Health Sciences
Medicine, Experimental
Metastasis
Microscope and microscopy
Microvasculature
Mortality
Multivariate analysis
Neoplasm Invasiveness - pathology
Neoplasm Recurrence, Local - pathology
Neoplastic Processes
Patient outcomes
Prognosis
Rank tests
Retrospective Studies
Surgery
Surveillance
Survival
Tumors
Citations: Items that this one cites
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Summary:To determine the impact of microvascular invasion (MVI) on outcome in patients with solitary hepatocellular carcinoma (HCC) of ≤ 2 cm undergoing liver resection (LR). This retrospective study enrolled consecutive patients between 2007-2019 with newly diagnosed solitary HCC ≤ 2 cm who were undergoing LR at our institution. Overall survival (OS) and recurrent-free survival (RFS) were compared between patients with or without MVI. Of the 229 patients included in this study, 71 had MVI. The median follow-up period was 28.8 months (interquartile range: 13.5-70.1). Although the 90-day mortality rate was 0, 18 deaths occurred during the study, and the 5-year survival rate was 87.1%. Tumor recurrence occurred in 45 cases, and 5-year RFS was 71.9%. The presence or absence of MVI did not significantly affect the OS and RFS rates (log rank test, p = 0.10 and 0.38, respectively). In univariate and multivariate analysis, the presence of MVI was not associated with OS and RFS. The presence of MVI was not associated with OS and RFS in patients with solitary HCC ≤ 2 cm who underwent LR in this cohort.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0281154