What bacterial cell death teaches us about life

Often this mechanistic division is poorly defined, but like the PCD of multicellular eukaryotes, bacterial Abi employs host-directed mechanisms to fend off pathogens. [...]bacterial Abi provides a window to further understand evolution of functionally analogous host-targeting systems in eukaryotes....

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Bibliographic Details
Published in:PLoS pathogens 2022-10, Vol.18 (10), p.e1010879
Main Authors: Johnson, Alex G, Kranzusch, Philip J
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Apoptosis
Appreciation
Aspartic acid
Bacteria
Biology and Life Sciences
C-Terminus
Caspase
Cell death
Eukaryotes
Evolution
Genomes
Infections
Leucine
Life (Biology)
Lysine
Mammals
Membranes
Mitochondria
Pathogens
Pearls
Peptides
Pore formation
Proteins
Pyroptosis
Residues
Signal transduction
Substrates
Viral infections
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Summary:Often this mechanistic division is poorly defined, but like the PCD of multicellular eukaryotes, bacterial Abi employs host-directed mechanisms to fend off pathogens. [...]bacterial Abi provides a window to further understand evolution of functionally analogous host-targeting systems in eukaryotes. Mammalian pyroptosis is induced by intracellular bacteria (and viral infection; not shown), leading to mGSDM activation through PAMPs or other signals, and pore formation on the plasma membrane, bacterial membranes, and mitochondria. [...]while mammalian caspases and the target protein substrates typically exist in isolated chromosomal loci, bacterial gasdermins are often encoded immediately adjacent to caspase-like and other proteases within genomic neighborhoods [14]. While all caspases studied to date cleave after an aspartic acid residue (or after arginine or lysine in distantly related relatives; [27]), bGSDMs are cleaved after leucine or arginine residues approximately 20 amino acids from the C-terminus [14].
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1010879