Relationship between finger movement characteristics and brain voxel-based morphometry

Aging is the most significant risk factor for dementia. Alzheimer's disease (AD) accounts for approximately 60-80% of all dementia cases in older adults. This study aimed to examine the relationship between finger movements and brain volume in AD patients using a voxel-based reginal analysis sy...

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Bibliographic Details
Published in:PloS one 2022-10, Vol.17 (10), p.e0269351
Main Authors: Sugioka, Junpei, Suzumura, Shota, Kuno, Katsumi, Kizuka, Shiori, Sakurai, Hiroaki, Kanada, Yoshikiyo, Mizuguchi, Tomohiko, Kondo, Izumi
Format: Article
Language:English
Subjects:
Aging
Alzheimer's disease
Atrophy
Biology and Life Sciences
Brain
Brain research
Cognitive ability
Correlation
Correlation coefficient
Correlation coefficients
Dementia
Dementia disorders
Diagnosis
Finger
Fingers
Fingers & toes
Geriatrics
Gerontology
Hand
Health aspects
Human mechanics
Magnetic resonance
Magnetic resonance imaging
Mathematical analysis
Medical imaging
Medicine and Health Sciences
Morphometry
Motor task performance
Neurodegenerative diseases
Neuroimaging
Neuropsychology
Older people
Parameters
Physiological aspects
Research and Analysis Methods
Risk analysis
Risk factors
Sensors
Substantia grisea
Temporal lobe
Tomography
Velocity
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Summary:Aging is the most significant risk factor for dementia. Alzheimer's disease (AD) accounts for approximately 60-80% of all dementia cases in older adults. This study aimed to examine the relationship between finger movements and brain volume in AD patients using a voxel-based reginal analysis system for Alzheimer's disease (VSRAD) software. Sixty-two patients were included in the study. Comparison between VSRAD and MoCA-J scores corrected for p-values showed a significant negative correlation with the extent of gray matter atrophy (r = -0. 52; p< 0.001). A positive correlation was observed between the severity of medial temporal lobe atrophy and standard deviation (SD) of the distance rate of velocity peak in extending movements in the non-dominant hand (r = 0. 51; p< 0.001). The SD of distance rate of velocity peak in extending movements extracted from finger taps may be a useful parameter for the early detection of AD and diagnosis of its severity.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0269351