Colon inflammatory index as a useful prognostic marker after R0 resection in patients with colorectal cancer liver metastasis

Although R0 resection for colorectal cancer liver metastasis (CRLM) is a promising treatment with improved prognosis, the recurrence rate is still high. No prognostic markers have been reported after resection of CRLM. In this study, we investigated the association between inflammation-based score a...

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Bibliographic Details
Published in:PloS one 2022-10, Vol.17 (10), p.e0273167-e0273167
Main Authors: Ishii, Mitsutoshi, Tominaga, Tetsuro, Nonaka, Takashi, Oyama, Shosaburo, Moriyama, Masaaki, Maruyama, Keizaburo, Sawai, Terumitsu, Nagayasu, Takeshi
Format: Article
Language:English
Subjects:
Albumins
Biology and Life Sciences
Cancer
Care and treatment
Chemotherapy
Colon
Colorectal cancer
Colorectal carcinoma
Colorectal surgery
Complications and side effects
Health aspects
Inflammation
Laboratories
Leukocytes
Liver
Liver cancer
Lymphocytes
Markers
Measurement
Medical prognosis
Medicine and Health Sciences
Metastases
Metastasis
Methods
Multivariate analysis
Neutrophils
Nutrition assessment
Patients
Prognosis
Risk
Surgery
Survival
Tumors
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Summary:Although R0 resection for colorectal cancer liver metastasis (CRLM) is a promising treatment with improved prognosis, the recurrence rate is still high. No prognostic markers have been reported after resection of CRLM. In this study, we investigated the association between inflammation-based score and prognosis after R0 resection in patients with CRLM. We retrospectively investigated 90 patients who underwent R0 resection for CRLM between 2008 and 2018. We calculated colon inflammatory index (CII) (CII0, low risk; CII1, intermediate risk; and CII2, high risk), modified Glasgow prognostic score, prognostic nutritional index, and CRP-to-albumin ratio; and retrospectively assessed the relationship between these scores, the clinicopathological features, and prognosis. The median follow-up period was 44 months (range, 2-101 months). Five-year relapse-free survival (RFS) (CII2; 12.5%, CII1; 14.5%, CII0; 42.9%) and 5-year overall survival (OS) (CII2; 32.4%, CII1; 25.4%, CII0; 57.7%) were significantly lower in the high CII groups (CII1-2) compared with the low CII group (CII0) (p = 0.021 and p = 0.006, respectively). CEA level was significantly higher in the high CII group than the low CII group (12.4 vs 7.3, p = 0.004). Multivariate analysis showed CII score as an independent predictor of RFS (hazard ratio 2.128, 95%CI 1.147-3.430, p = 0.015) and OS (hazard ratio 2.639, 95%CI 1.331-5.323, p = 0.005). CII shows promise as a prognostic marker after R0 liver resection in patients with CRLM.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0273167