Development of an observational exposure human biomonitoring study to assess Canadian children’s DEET exposure during protective use

Biomonitoring data of N,N-diethyl-meta-toluamide (DEET) in children is scarce and limited to controlled exposure and surveillance studies. We conducted a 24-hour observational exposure and human biomonitoring study designed to estimate use of and exposure to DEET-based insect repellents by Canadian...

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Bibliographic Details
Published in:PloS one 2022-08, Vol.17 (8), p.e0268341
Main Authors: Gibson, Jennifer C, Marro, Leonora, Borghese, Michael M, Brandow, Danielle, Remedios, Lauren, Fisher, Mandy, Malowany, Morie, Kieliszkiewicz, Katarzyna, Lukina, Anna O, Irwin, Kim
Format: Article
Language:English
Subjects:
Age
Benzamide
Benzoic acid
Biological monitoring
Biology and Life Sciences
Biomonitoring
Camps
Children
Consent
Contraindications
Data collection
DEET
Evaluation
Exposure
Health aspects
Insecticides
Insects
Medicine and Health Sciences
Metabolites
Packaging
People and Places
Physical Sciences
Population
Quality control
Questionnaires
Repellents
Research and Analysis Methods
Skin
Time dependence
Urine
West Nile virus
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Summary:Biomonitoring data of N,N-diethyl-meta-toluamide (DEET) in children is scarce and limited to controlled exposure and surveillance studies. We conducted a 24-hour observational exposure and human biomonitoring study designed to estimate use of and exposure to DEET-based insect repellents by Canadian children in an overnight summer camp setting. Here, we present our study design and methodology. In 2019, children between the ages of 7 and 13 took part in the study (n = 126). Children controlled their use of DEET-based insect repellents, and provided an account of their activities at camp that could impact insect repellent absorption. Children provided a total of 389 urine samples throughout the study day, and reported the time that they applied insect repellent, which allowed us to contextualize urinary DEET and metabolite concentrations with respect to the timing of insect repellent application. DEET (2.3%
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0268341