Apelin and its ratio to lipid factors are associated with cardiovascular diseases: A systematic review and meta-analysis

The present systematic review and meta-analysis aimed to ascertain if the circulating levels of apelin, as an important regulator of the cardiovascular homeostasis, differ in patients with cardiovascular diseases (CVDs) and controls. A comprehensive search was performed in electronic databases inclu...

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Published in:PloS one 2022-08, Vol.17 (8), p.e0271899-e0271899
Main Authors: Akbari, Hamed, Hosseini-Bensenjan, Mahnaz, Salahi, Sarvenaz, Moazzen, Fatemeh, Aria, Hamid, Manafi, Alireza, Hosseini, Saeed, Niknam, Maryam, Asadikaram, Gholamreza
Format: Article
Language:English
Subjects:
Angina pectoris
Bias
Biology and Life Sciences
Biomarkers
Cardiac arrhythmia
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Collection Review
Complications and side effects
Coronary vessels
Density
Diabetes
Diabetes mellitus
Diagnosis
Health aspects
Heart attacks
Heart failure
High density lipoprotein
Homeostasis
Lipids
Lipoproteins
Low density lipoprotein
Medicine and Health Sciences
Meta-analysis
Metabolism
Peptides
Physical Sciences
Research and Analysis Methods
Systematic review
Triglycerides
Vein & artery diseases
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Summary:The present systematic review and meta-analysis aimed to ascertain if the circulating levels of apelin, as an important regulator of the cardiovascular homeostasis, differ in patients with cardiovascular diseases (CVDs) and controls. A comprehensive search was performed in electronic databases including PubMed, Scopus, EMBASE, and Web of Science to identify the studies addressing apelin in CVD up to April 5, 2021. Due to the presence of different units to measure the circulating levels of apelin across the included studies, they expressed the standardized mean difference (SMD) and their 95% confidence interval (CI) as summary effect size. A random-effects model comprising DerSimonian and Laird method was used to pool SMDs. Twenty-four articles (30 studies) comprised of 1793 cases and 1416 controls were included. Pooled results obtained through random-effects model indicated that apelin concentrations in the cases' blood samples were significantly lower than those of the control groups (SMD = -0.72, 95% CI: -1.25, -0.18, P = 0.009; I.sup.2 = 97.3%, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0271899