Elevated alpha-fetoprotein in asymptomatic adults: Clinical features, outcome, and association with body composition

Apparently healthy individuals with elevated serum alpha-fetoprotein (AFP) levels (>7 ng/mL) for unknown causes visit clinics. We investigated their clinical characteristics, outcomes, and relationship with body fat deposition and muscle mass. The case group included asymptomatic 137 individuals...

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Bibliographic Details
Published in:PloS one 2022-07, Vol.17 (7), p.e0271407-e0271407
Main Authors: Jang, Sangmi, Choi, Gwang Hyeon, Chang, Won, Jang, Eun Sun, Kim, Jin-Wook, Jeong, Sook-Hyang
Format: Article
Language:English
Subjects:
Adipose tissue
Age
Alanine
Alanine transaminase
Alpha fetoproteins
Asymptomatic
Bilirubin
Biology and Life Sciences
Body composition
Body fat
Body mass
Body mass index
Body size
Cancer
Computed tomography
Diabetes
Fatty liver
Glucose
Hemangioma
Hepatitis
Hospitals
Image contrast
Laboratories
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Medical imaging
Medicine and Health Sciences
Muscles
Ovaries
Patients
Phenotypes
Properties
Psoas muscle
Research and Analysis Methods
Sarcopenia
Steatosis
Subgroups
Tertiary
Variables
α-Fetoprotein
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Summary:Apparently healthy individuals with elevated serum alpha-fetoprotein (AFP) levels (>7 ng/mL) for unknown causes visit clinics. We investigated their clinical characteristics, outcomes, and relationship with body fat deposition and muscle mass. The case group included asymptomatic 137 individuals with "elevated AFP level" (R772) diagnostic code from 2009 to 2018 in a tertiary hospital. The control group enrolled 274 age- and sex-matched patients with
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0271407