Referential equations for pulmonary diffusing capacity using GAMLSS models derived from Japanese individuals with near-normal lung function

To generate appropriate reference values for the single-breath diffusing capacity of the lungs for carbon monoxide (D.sub.LCO ), alveolar volume (V.sub.A ), and the transfer coefficient of the lungs for carbon monoxide (K.sub.CO, often denoted as D.sub.LCO /V.sub.A) in the Japanese population. We al...

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Bibliographic Details
Published in:PloS one 2022-07, Vol.17 (7), p.e0271129
Main Authors: Wada, Yosuke, Goto, Norihiko, Kitaguchi, Yoshiaki, Yasuo, Masanori, Hanaoka, Masayuki
Format: Article
Language:English
Subjects:
Age groups
Alveoli
Biology and Life Sciences
Body mass index
Carbon monoxide
Chronic obstructive pulmonary disease
Consent
Diagnosis
Females
Health aspects
Lung diseases
Lungs
Mathematical models
Medicine and Health Sciences
Physical Sciences
Population
Research and Analysis Methods
Respiratory function
Skewness
Values
White people
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Summary:To generate appropriate reference values for the single-breath diffusing capacity of the lungs for carbon monoxide (D.sub.LCO ), alveolar volume (V.sub.A ), and the transfer coefficient of the lungs for carbon monoxide (K.sub.CO, often denoted as D.sub.LCO /V.sub.A) in the Japanese population. We also intended to assess the applicability of these values for the Japanese population by comparing them to those published by the Global Lung Function Initiative in 2017 (GLI-2017) and previous values. In this retrospective study, we measured the spirometric indices, D.sub.LCO, V.sub.A, and K.sub.CO of the Japanese population aged 16-85 years. The lambda, mu, and sigma (LMS) method and the generalized additive models for the location, scale, and shape program in R were used to generate the reference values. We conducted a total of 390 tests. The GLI-2017 z-scores of D.sub.LCO were approximately zero, whereas those of K.sub.CO and V.sub.A were far from zero. In the present study, the mean square errors of the D.sub.LCO, V.sub.A, and K.sub.CO reference values were lower than the reference values derived from GLI-2017 and previous linear regression equations. Reference values obtained in this study were more appropriate for our sample than those reported in GLI-2017. Differences between the two equations were attributed to underestimating K.sub.CO (D.sub.LCO / V.sub.A) and overestimating V.sub.A, respectively, by the GLI-2017 for the Japanese population.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0271129