Plasma metabolomic analysis indicates flavonoids and sorbic acid are associated with incident diabetes: A nested case-control study among Women's Interagency HIV Study participants

Lifestyle improvements are key modifiable risk factors for Type 2 diabetes mellitus (DM) however specific influences of biologically active dietary metabolites remain unclear. Our objective was to compare non-targeted plasma metabolomic profiles of women with versus without confirmed incident DM. We...

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Published in:	PloS one 2022-07, Vol.17 (7), p.e0271207-e0271207
Main Authors:	Yu, Elaine A, Alemán, José O, Hoover, Donald R, Shi, Qiuhu, Verano, Michael, Anastos, Kathryn, Tien, Phyllis C, Sharma, Anjali, Kardashian, Ani, Cohen, Mardge H, Golub, Elizabeth T, Michel, Katherine G, Gustafson, Deborah R, Glesby, Marshall J
Format:	Article
Language:	eng
Subjects:	Analysis Bioflavonoids Biological activity Biology and Life Sciences Case-Control Studies Chromatography Demographic aspects Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes therapy Diet Discriminant analysis Evaluation Fasting Female Flavones Flavonoids Glucose Health aspects HIV HIV (Viruses) HIV Infections - complications HIV Infections - epidemiology Human immunodeficiency virus Humans Ionization Isoflavones Lipids Liquid chromatography Mass spectrometry Mass spectroscopy Medicine and Health Sciences Metabolism Metabolites Metabolomics Methods Plasma Polyketides Regression analysis Regression models Risk analysis Risk Factors Scientific imaging Sorbic Acid Type 2 diabetes Viruses Women
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Summary:	Lifestyle improvements are key modifiable risk factors for Type 2 diabetes mellitus (DM) however specific influences of biologically active dietary metabolites remain unclear. Our objective was to compare non-targeted plasma metabolomic profiles of women with versus without confirmed incident DM. We focused on three lipid classes (fatty acyls, prenol lipids, polyketides). Fifty DM cases and 100 individually matched control participants (80% with human immunodeficiency virus [HIV]) were enrolled in a case-control study nested within the Women's Interagency HIV Study. Stored blood samples (1-2 years prior to DM diagnosis among cases; at the corresponding timepoint among matched controls) were assayed in triplicate for metabolomics. Time-of-flight liquid chromatography mass spectrometry with dual electrospray ionization modes was utilized. We considered 743 metabolomic features in a two-stage feature selection approach with conditional logistic regression models that accounted for matching strata. Seven features differed by DM case status (all false discovery rate-adjusted q
ISSN:	1932-6203 1932-6203