Innate immunity in fungi: Is regulated cell death involved?

Because of these conditions, fungi are expected to share molecular underpinnings of their immune responses with animals, while being able to mount them in most vegetative cells of their bodies, like plants and in contrast to animals, which rely on specialized immune cells, phagocytes. [...]in the ea...

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Bibliographic Details
Published in:PLoS pathogens 2022-05, Vol.18 (5), p.e1010460-e1010460
Main Authors: Gaspar, Maria Laura, Pawlowska, Teresa E
Format: Article
Language:English
Subjects:
Amino acids
Animals
Apoptosis
Autophagy
Bacteria
Biology and Life Sciences
Care and treatment
Cell Death
Cell envelopes
Chromatin
Cysteine
Defensins
Development and progression
E coli
Fungi
Health aspects
Host-parasite relationships
Immune response
Immune system
Immunity, Innate
Innate immunity
Ligands
Medicine and Health Sciences
Metabolites
Mycoses
Observations
Pathogens
Pearls
Phagocytes
Phagocytosis
Plants (botany)
Proteins
Regulated Cell Death
Signal transduction
Vegetative cells
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Summary:Because of these conditions, fungi are expected to share molecular underpinnings of their immune responses with animals, while being able to mount them in most vegetative cells of their bodies, like plants and in contrast to animals, which rely on specialized immune cells, phagocytes. [...]in the early divergent mold Rhizopus microsporus challenged by Mycetohabitans sp., ROS accumulation is accompanied by upregulation of genes responsible for producing ROS and causing oxidative damage through prooxidant activity [9]. (ii) AMPs are small (approximately 100 amino acids) cysteine-rich molecules that disrupt bacterial cell envelopes [19]. [...]the coprophilous mushroom Coprinopsis cinerea produces cysteine stabilized αβ-defensins and GH24-type lysozymes when co-cultivated with Bacillus subtilis and Escherichia coli [22]. (iii) ETs are web-like structures composed of decondensed chromatin and granular proteins, including AMPs, which bind and kill bacteria [20]. [...]autophagy was observed in the model ascomycete Podospora anserina confronted with antagonistic bacteria Serratia fonticola and Serratia marcescens [28].
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1010460