Incidence of chikungunya virus infections among Kenyan children with neurological disease, 2014-2018: A cohort study

Neurological complications due to chikungunya virus (CHIKV) infection have been described in different parts of the world, with children being disproportionately affected. However, the burden of CHIKV-associated neurological disease in Africa is currently unknown and given the lack of diagnostic fac...

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Published in:PLoS medicine 2022-05, Vol.19 (5), p.e1003994
Main Authors: Nyamwaya, Doris K, Otiende, Mark, Mwango, Lilian, Kariuki, Symon M, Otieno, Berrick, Omuoyo, Donwilliams O, Githinji, George, Kitsao, Barnes S, Karanja, Henry K, Gitonga, John N, de Laurent, Zaydah R, Davies, Alun, Mwarumba, Salim, Agoti, Charles N, Thumbi, Samuel M, Hamaluba, Mainga M, Newton, Charles R, Bejon, Philip, Warimwe, George M
Format: Article
Language:English
Subjects:
Biology and life sciences
Blood
Cerebrospinal fluid
Chikungunya virus
Children
Coasts
Cohort analysis
Coma
Complications and side effects
Development and progression
Encephalitis
Epidemics
Etiology
Genomes
Hospitalization
Illnesses
Infections
Laboratories
Malaria
Medical research
Medicine and Health Sciences
Meningitis
Migration
Nervous system diseases
Neurological complications
Neurological diseases
Pediatric research
Pediatrics
People and Places
Polymerase chain reaction
Research and Analysis Methods
Risk factors
RNA-directed DNA polymerase
Seizures
Surveillance
Vectors
Virus diseases
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Summary:Neurological complications due to chikungunya virus (CHIKV) infection have been described in different parts of the world, with children being disproportionately affected. However, the burden of CHIKV-associated neurological disease in Africa is currently unknown and given the lack of diagnostic facilities in routine care it is possible that CHIKV is an unrecognized etiology among children with encephalitis or other neurological illness. We estimated the incidence of CHIKV infection among children hospitalized with neurological disease in Kilifi County, coastal Kenya. We used reverse transcriptase polymerase chain reaction (RT-PCR) to systematically test for CHIKV in cerebrospinal fluid (CSF) samples from children aged
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1003994