Maternal body composition and gestational weight gain in relation to asthma control during pregnancy

Poor asthma control is common during pregnancy and contributes to adverse pregnancy outcomes. Identification of risk factors for poor gestational asthma control is crucial. Examine associations of body composition and gestational weight gain with asthma control in a prospective pregnancy cohort (n =...

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Bibliographic Details
Published in:	PloS one 2022-04, Vol.17 (4), p.e0267122-e0267122
Main Authors:	Stevens, Danielle R, Rohn, Matthew C H, Hinkle, Stefanie N, Williams, Andrew D, Kumar, Rajesh, Lipsky, Leah M, Grobman, William, Sherman, Seth, Kanner, Jenna, Chen, Zhen, Mendola, Pauline
Format:	Article
Language:	eng
Subjects:	Adipose tissue Adiposity Analysis Asthma Biology and Life Sciences Body composition Body composition (biology) Body mass Body Mass Index Body size Body weight gain Care and treatment Childrens health Confidence intervals Diaries Evaluation Female Gestational Weight Gain Health aspects Health risks Humans Inhalers Lungs Medical records Medical research Medicine and Health Sciences Night Obesity Physiological aspects Population Pregnancy Pregnant women Prognosis Prospective Studies Questionnaires Respiratory agents Respiratory function Risk analysis Risk factors Spirometry Symptomology Vital Capacity Weight Weight Gain Womens health
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Summary:	Poor asthma control is common during pregnancy and contributes to adverse pregnancy outcomes. Identification of risk factors for poor gestational asthma control is crucial. Examine associations of body composition and gestational weight gain with asthma control in a prospective pregnancy cohort (n = 299). Exposures included pre-pregnancy body mass index (BMI), first trimester skinfolds, and trimester-specific gestational weight gain. Outcomes included percent predicted forced expiratory volumes (FEV1, FEV6), forced vital capacity (FVC), peak expiratory flow (PEF), FEV1/FVC, symptoms (activity limitation, nighttime symptoms, inhaler use, and respiratory symptoms), and exacerbations (asthma attacks, medical encounters). Linear and Poisson models examined associations with lung function (β (95% confidence interval (CI)), asthma symptom burden (relative rate ratio (RR (95%CI)), and exacerbations (RR (95%CI)). Women with a BMI ≥ 30 had lower percent predicted FVC across pregnancy (βThirdTrimester: -5.20 (-8.61, -1.78)) and more frequent night symptoms in the first trimester (RR: 1.66 (1.08, 2.56)). Higher first trimester skinfolds were associated with lower FEV1, FEV6, and FVC, and more frequent night symptoms and inhaler use across pregnancy. Excessive first trimester gestational weight gain was associated with more frequent activity limitation in the first trimester (RR: 3.36 (1.15, 9.80)) and inhaler use across pregnancy (RRThirdTrimester: 3.49 (1.21, 10.02)). Higher adiposity and first trimester excessive gestational weight gain were associated with restrictive changes in lung function and symptomology during pregnancy.
ISSN:	1932-6203 1932-6203