The effect of transverse ocular magnification adjustment on macular thickness profile in different refractive errors in community-based adults

Changes in retinal thickness are common in various ocular diseases. Transverse magnification due to differing ocular biometrics, in particular axial length, affects measurement of retinal thickness in different regions. This study evaluated the effect of axial length and refractive error on measured...

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Bibliographic Details
Published in:PloS one 2022-04, Vol.17 (4), p.e0266909-e0266909
Main Authors: Niyazmand, Hamed, Lingham, Gareth, Sanfilippo, Paul G, Blaszkowska, Magdalena, Franchina, Maria, Yazar, Seyhan, Alonso-Caneiro, David, Mackey, David A, Lee, Samantha Sze-Yee
Format: Article
Language:English
Subjects:
Adults
Biology and Life Sciences
Biometrics
Biometry
Care and treatment
Coherence (Optics)
Complications and side effects
Computer and Information Sciences
Diabetes mellitus
Diabetic Retinopathy
Engineering and Technology
Error analysis
Error correction
Eye diseases
Hospitals
Humans
Laboratories
Macula Lutea - diagnostic imaging
Medicine and Health Sciences
Myopia
Ophthalmology
Optics
Optometry
Patient outcomes
People and Places
Refraction, Ocular
Refractive Errors
Research and Analysis Methods
Retina
Retinopathy
Thickness measurement
Tomography
Tomography, Optical Coherence - methods
Young Adult
Young adults
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Summary:Changes in retinal thickness are common in various ocular diseases. Transverse magnification due to differing ocular biometrics, in particular axial length, affects measurement of retinal thickness in different regions. This study evaluated the effect of axial length and refractive error on measured macular thickness in two community-based cohorts of healthy young adults. A total of 2160 eyes of 1247 community-based participants (18-30 years; 23.4% myopes, mean axial length = 23.6mm) were included in this analysis. Macular thickness measurements were obtained using a spectral-domain optical coherence tomography (which assumes an axial length of 24.385mm). Using a custom program, retinal thickness data were extracted at the 9 Early Treatment of Diabetic Retinopathy Study (ETDRS) regions with and without correction for transverse magnificent effects, with the corrected measurements adjusting according to the participant's axial length. Linear mixed models were used to analyse the effect of correction and its interaction with axial length or refractive group on retinal thickness. The raw measures (uncorrected for axial length) underestimated the true retinal thickness at the central macula, while overestimating at most non-central macular regions. There was an axial length by correction interaction effect in all but the nasal regions (all p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0266909