Multiple metals influence distinct properties of the Arabidopsis circadian clock

Circadian rhythms coordinate endogenous events with external signals, and are essential to biological function. When environmental contaminants affect these rhythms, the organism may experience fitness consequences such as reduced growth or increased susceptibility to pathogens. In their natural env...

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Bibliographic Details
Published in:PloS one 2022-04, Vol.17 (4), p.e0258374-e0258374
Main Authors: Hargreaves, Jessica K, Oakenfull, Rachael J, Davis, Amanda M, Pullen, Freya, Knight, Marina I, Pitchford, Jon W, Davis, Seth J
Format: Article
Language:English
Subjects:
Agricultural land
Arabidopsis
Arabidopsis - physiology
Arabidopsis Proteins - genetics
Biological clocks
Biology
Biology and Life Sciences
Circadian Clocks
Circadian rhythm
Circadian Rhythm - physiology
Circadian rhythms
Clustering
Contaminants
Environmental aspects
Environmental changes
Health aspects
Heavy metals
Hypothesis testing
Industrial pollution
Laboratories
Mathematics
Metals
Methods
Organisms
Periodicity
Physical Sciences
Physiological aspects
Physiology
Pollutants
Research and Analysis Methods
Salts
Sediment pollution
Soil contamination
Soil investigations
Soil pollution
Time series
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Summary:Circadian rhythms coordinate endogenous events with external signals, and are essential to biological function. When environmental contaminants affect these rhythms, the organism may experience fitness consequences such as reduced growth or increased susceptibility to pathogens. In their natural environment plants may be exposed to a wide range of industrial and agricultural soil pollutants. Here, we investigate how the addition of various metal salts to the root-interaction environment can impact rhythms, measured via the promoter:luciferase system. The consequences of these environmental changes were found to be varied and complex. Therefore, in addition to traditional Fourier-based analyses, we additionally apply novel wavelet-based spectral hypothesis testing and clustering methodologies to organize and understand the data. We are able to classify broad sets of responses to these metal salts, including those that increase, and those that decrease, the period, or which induce a lack of precision or disrupt any meaningful periodicity. Our methods are general, and may be applied to discover common responses and hidden structures within a wide range of biological time series data.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0258374