The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol

People living with HIV (PLHIV) present impaired muscle metaboreflex, which may lead to exercise intolerance and increased cardiovascular risk. The muscle metaboreflex adaptations to exercise training in these patients are unknown. The present study aims to investigate the effects of a supervised mul...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2022-03, Vol.17 (3), p.e0265516-e0265516
Main Authors: Gama, Gabriel, Dos Santos Rangel, Marcus Vinicius, de Oliveira Coelho, Vanessa Cunha, Paz, Gabriela Andrade, de Matos, Catarina Vieira Branco, Silva, Bárbara Pinheiro, Lopes, Gabriella de Oliveira, Lopes, Karynne Grutter, Farinatti, Paulo, Borges, Juliana Pereira
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adaptation
AIDS
AIDS (Disease)
Biology and Life Sciences
Blood Pressure
Capsaicin
Cardiac output
Cardiovascular disease
Cardiovascular diseases
Clinical trials
Evaluation
Exercise
Exercise - physiology
Fitness training programs
Hand Strength
Health aspects
Health promotion
Health risks
Heart failure
Heart Rate
Hemodynamic monitoring
Hemodynamic responses
Hemodynamics
Hemodynamics - physiology
HIV
HIV Infections - therapy
Human immunodeficiency virus
Humans
Hypertension
Immune system
Intolerance
Laboratories
Lactic acid
Medicine and Health Sciences
Muscle Contraction
Muscle, Skeletal - physiology
Muscles
Physical education
Physical fitness
Physical training
Prevention
Psychological stress
Randomized Controlled Trials as Topic
Reflex - physiology
Research and Analysis Methods
Stroke volume
Study Protocol
Training
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:People living with HIV (PLHIV) present impaired muscle metaboreflex, which may lead to exercise intolerance and increased cardiovascular risk. The muscle metaboreflex adaptations to exercise training in these patients are unknown. The present study aims to investigate the effects of a supervised multimodal exercise training on hemodynamic and autonomic responses to muscle metaboreflex activation in PLHIV. In this randomized clinical trial protocol, 42 PLHIV aged 30-50 years will be randomly assigned at a ratio of 1:1 into an intervention or a control group. The intervention group will perform exercise training (3x/week during 12 weeks) and the control group will remain physically inactive. A reference group composed of 21 HIV-uninfected individuals will be included. Primary outcomes will be blood pressure and heart rate variability indices assessed during resting, mental stress, and activation of muscle metaboreflex by a digital sphygmomanometer and a heart rate monitor; respectively. Mental stress will be induced by the Stroop Color-Word test and muscle metaboreflex will be activated through a post-exercise circulatory arrest (PECA) protocol, being the latter performed without and with the application of a capsaicin-based analgesic balm in the exercised limb. Secondary outcomes will be heart rate, peripheral vascular resistance, stroke volume, cardiac output, blood lactate, anthropometric markers and handgrip maximal voluntary contraction. The intervention and control groups of PLHIV will be evaluated at baseline and after the intervention, while the HIV-uninfected reference group only at baseline. The findings of the present study may help to elucidate the muscle metaboreflex adaptations to exercise training in PLHIV. This study will be performed at University of Rio de Janeiro State following registration at ClinicalTrials.gov as NCT04512456 on August 13, 2020.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0265516