Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses

Schistosomiasis is a potentially lethal parasitic disease that profoundly impacts systemic immune function in chronically infected hosts through mechanisms that remain unknown. Given the immunoregulatory dysregulation experienced in infected individuals, this study examined the impact of chronic sch...

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Bibliographic Details
Published in:PLoS pathogens 2022-02, Vol.18 (2), p.e1010327-e1010327
Main Authors: Musaigwa, Fungai, Kamdem, Severin Donald, Mpotje, Thabo, Mosala, Paballo, Abdel Aziz, Nada, Herbert, De'Broski R, Brombacher, Frank, Nono, Justin Komguep
Format: Article
Language:English
Subjects:
Age
Analysis
Animals
Antibodies
Biology and Life Sciences
Bone Marrow
Cell Death
Chronic infection
Developing countries
Guardians
Immune response
Immunological memory
Immunoregulation
Infections
LDCs
Medicine and Health Sciences
Mice
Mortality
Parasites
Parasitic diseases
Patient outcomes
Plasma
Plasma Cells
Praziquantel
Rodents
Schistosoma mansoni
Schistosomiasis
Schistosomiasis mansoni
Schools
Serology
Sustainability
Tropical diseases
Vaccination
Vaccines
Vaccines - therapeutic use
Viral vaccines
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Summary:Schistosomiasis is a potentially lethal parasitic disease that profoundly impacts systemic immune function in chronically infected hosts through mechanisms that remain unknown. Given the immunoregulatory dysregulation experienced in infected individuals, this study examined the impact of chronic schistosomiasis on the sustainability of vaccine-induced immunity in both children living in endemic areas and experimental infections in mice. Data show that chronic Schistosoma mansoni infection impaired the persistence of vaccine specific antibody responses in poliovirus-vaccinated humans and mice. Mechanistically, schistosomiasis primarily fostered plasmablast and plasma cell death in the bone marrow and removal of parasites following praziquantel treatment reversed the observed cell death and partially restored vaccine-induced memory responses associated with increased serum anti-polio antibody responses. Our findings strongly suggest a previously unrecognized mechanism to explain how chronic schistosomiasis interferes with an otherwise effective vaccine regimen and further advocates for therapeutic intervention strategies that reduce schistosomiasis burden in endemic areas prior to vaccination.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1010327