Predictors of life-threatening complications in relatively lower-risk patients hospitalized with COVID-19

Older individuals with chronic health conditions are at highest risk of adverse clinical outcomes from COVID-19, but there is widespread belief that risk to younger, relatively lower-risk individuals is negligible. We assessed the rate and predictors of life-threatening complications among relativel...

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Bibliographic Details
Published in:PloS one 2022-02, Vol.17 (2), p.e0263995-e0263995
Main Authors: Gonzalez, Christopher J, Hogan, Cameron J, Rajan, Mangala, Wells, Martin T, Safford, Monika M, Pinheiro, Laura C, Ghosh, Arnab K, Choi, Justin J, Burchenal, Clare A, Shah, Pooja D, Shapiro, Martin F
Format: Article
Language:English
Subjects:
Adults
Age Factors
Biology and Life Sciences
Chronic illnesses
Comorbidity
Complications
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - ethnology
COVID-19 - pathology
COVID-19 - virology
Epidemics
Female
Forecasts and trends
Government programs
Health risks
Hospital Mortality
Hospitalization - statistics & numerical data
Humans
Hypertension
Hypertension - complications
Insurance
Intubation
Length of Stay
Logistic Models
Male
Medicine and Health Sciences
Middle Aged
Minority & ethnic groups
New York City
Obesity
Patients
People and Places
Poverty
Proportional Hazards Models
Regression analysis
Regression models
Retrospective Studies
Risk
Risk Factors
SARS-CoV-2 - isolation & purification
Severity of Illness Index
Sex
Sex Factors
Social factors
Socioeconomic factors
United States
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Summary:Older individuals with chronic health conditions are at highest risk of adverse clinical outcomes from COVID-19, but there is widespread belief that risk to younger, relatively lower-risk individuals is negligible. We assessed the rate and predictors of life-threatening complications among relatively lower-risk adults hospitalized with COVID-19. Of 3766 adults hospitalized with COVID-19 to three hospitals in New York City from March to May 2020, 963 were relatively lower-risk based on absence of preexisting health conditions. Multivariable logistic regression models examined in-hospital development of life-threatening complications (major medical events, intubation, or death). Covariates included age, sex, race/ethnicity, hypertension, weight, insurance type, and area-level sociodemographic factors (poverty, crowdedness, and limited English proficiency). In individuals ≥55 years old (n = 522), 33.3% experienced a life-threatening complication, 17.4% were intubated, and 22.6% died. Among those
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0263995