The association between migraine and breast cancer risk: A systematic review and meta-analysis

Migraines is likely to play a protective role in the risk of breast cancer. Some studies have shown that there is an inverse relationship between migraine and breast cancer, and some studies have not found an association; therefore, results from previous studies have been inconclusive and we conduct...

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Bibliographic Details
Published in:PloS one 2022-02, Vol.17 (2), p.e0263628-e0263628
Main Authors: Hesari, Elahe, Ahmadinezhad, Mozhgan, Arshadi, Maedeh, Azizi, Hosein, Khodamoradi, Farzad
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Breast cancer
Breast Neoplasms - epidemiology
Carcinoma, Ductal, Breast - epidemiology
Carcinoma, Lobular - epidemiology
Confidence intervals
Development and progression
Epidemiology
Estrogen
Estrogens
Female
Headache
Health aspects
Health risks
Hormones
Humans
Medicine and Health Sciences
Menstruation
Meta-analysis
Migraine
Migraine Disorders - epidemiology
Observational Studies as Topic
Pathogenesis
People and places
Physical Sciences
Physiological aspects
Public health
Publication Bias
Research and Analysis Methods
Risk
Risk Assessment
Risk factors
Statistical analysis
Tumors
Womens health
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Summary:Migraines is likely to play a protective role in the risk of breast cancer. Some studies have shown that there is an inverse relationship between migraine and breast cancer, and some studies have not found an association; therefore, results from previous studies have been inconclusive and we conducted a meta-analysis to evaluate association between migraine and breast cancer. PubMed, EMBASE, Scopus and Web of Science were searched to identify studies on the association between migraine and breast cancer from January 1, 2000 through March 12, 2021. The pooled relative risk (RR) and the 95% confidence intervals (CI) was used to measure this relationship by assuming a random effects meta-analytic model. A total of 10 studies were included. Our study revealed that there was statistically significant inverse relationship between migraine and breast cancer in case-control studies 0.68 [95% CI: 0.56, 0.82], but no significant relationship was found in cohort studies 0.98 [95% CI: 0.91, 1.06]. Also, migraine reduced the risk of ductal carcinoma 0.84 [95% CI: 0.73, 0.96], and lobular carcinoma 0.83 [95% CI: 0.73, 0.96]. With respect to ER_PR status no association between migraine and breast cancer was found. We found no evidence of publication bias. Our analysis demonstrated a statistically significantly inverse relationship between migraine and total risk of breast cancer only in case-control studies. In summary, cohort studies do not support an inverse association between migraine and incident breast cancer. While in case-control studies, migraine has an inverse association with ductal carcinoma and lobular carcinoma of breast.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0263628