Predicting the risk of atherosclerotic cardiovascular disease among adults living with HIV/AIDS in Addis Ababa, Ethiopia: A hospital-based study

Atherosclerotic Cardiovascular Disease (ASCVD) is an emerging problem among People living with HIV/AIDS (PLWHA). The current study aimed at determining the risk of ASCVD among PLWHA using the Pooled Cohort Equation (PCE) and the Framingham Risk score (FRS). A hospital-based study was carried out fro...

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Bibliographic Details
Published in:PloS one 2021-11, Vol.16 (11), p.e0260109-e0260109
Main Authors: Woldu, Minyahil, Minzi, Omary, Shibeshi, Workineh, Shewaamare, Aster, Engidawork, Ephrem
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - complications
Adult
Adults
Age
Aged
AIDS
Arteriosclerosis
Atherosclerosis
Atherosclerosis - genetics
Biology and Life Sciences
Blood pressure
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - genetics
Cholesterol
Complications and side effects
Coronary Artery Disease - genetics
Coronary Artery Disease - metabolism
Coronary Artery Disease - prevention & control
Data collection
Demographic aspects
Ethiopia - epidemiology
Family medical history
Female
Gender
Health risks
Health sciences
HIV
HIV Infections - complications
HIV Infections - genetics
HIV patients
Hospitals
Human immunodeficiency virus
Humans
Hypertension
Life expectancy
Logistic Models
Male
Males
Medicine and Health Sciences
Middle Aged
Mortality
Odds Ratio
Pharmacology
Pharmacy
Population
Prevalence
Prognosis
Public health
Questionnaires
Risk Factors
Risk management
Sample size
Smoking
Social Sciences
Tobacco Smoking
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Summary:Atherosclerotic Cardiovascular Disease (ASCVD) is an emerging problem among People living with HIV/AIDS (PLWHA). The current study aimed at determining the risk of ASCVD among PLWHA using the Pooled Cohort Equation (PCE) and the Framingham Risk score (FRS). A hospital-based study was carried out from January 2019 to February 2020 in PLWHA. The prevalence of ASCVD risk was determined in individuals aged between 20 to 79 and 40 to 79 years using the FRS and PCE as appropriate. Chi-square, univariate and multivariate logistic regressions were employed for analysis. The prevalence of high-risk ASCVD for subjects aged 20 and above using both tools was 11.5 %. For those aged 40 to 79 years, PCE yielded an increased risk (28%) than FRS (17.7%). Using both tools; advanced age, male gender, smoking, and increased systolic blood pressure were associated with an increased risk of ASCVD. Younger age (adjusted odds ratio, AOR) 0.20, 95%CI: 0.004, 0.091; P< 0.001), lower systolic blood pressure (AOR 0.221, 95%CI: 0.074, 0.605 P< 0.004), and lower total cholesterol (AOR 0.270, 95%CI: 0.073, 0.997; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0260109