Association between hepatic oxygenation on near-infrared spectroscopy and clinical factors in patients undergoing hemodialysis

The hepato-splanchnic circulation directly influences oxygenation of the abdominal organs and plays an important role in compensating for the blood volume reduction that occurs in the central circulation during hemodialysis (HD) with ultrafiltration. However, the hepato-splanchnic circulation and ox...

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Bibliographic Details
Published in:PloS one 2021-10, Vol.16 (10), p.e0259064-e0259064
Main Authors: Ueda, Yuichiro, Ookawara, Susumu, Ito, Kiyonori, Sasabuchi, Yusuke, Hayasaka, Hideyuki, Kofuji, Masaya, Uchida, Takayuki, Imai, Sojiro, Kiryu, Satoshi, Minato, Saori, Miyazawa, Haruhisa, Sanayama, Hidenori, Hirai, Keiji, Tabei, Kaoru, Morishita, Yoshiyuki
Format: Article
Language:English
Subjects:
Albumin
Biology and Life Sciences
Blood
Blood circulation
Blood gases
Blood pressure
Blood volume
Body mass
Body mass index
Body size
Cardiovascular diseases
Coefficients
Disease
Health aspects
Hemodialysis
Hemoglobin
Hospitals
Hypotension
Infrared spectra
Infrared spectroscopy
Integrative medicine
Liver
Medicine
Medicine and Health Sciences
Near infrared radiation
Near infrared spectroscopy
Nephrology
Organs
Osmosis
Osmotic pressure
Oxygen
Oxygen content
Oxygen saturation
Oxygenation
Patients
Physical Sciences
Physiological aspects
Regional blood flow
Regression analysis
Regression models
Research and Analysis Methods
Sensors
Serum albumin
Spectrum analysis
Ueda, Susumu
Ultrafiltration
Ultrasonic imaging
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Summary:The hepato-splanchnic circulation directly influences oxygenation of the abdominal organs and plays an important role in compensating for the blood volume reduction that occurs in the central circulation during hemodialysis (HD) with ultrafiltration. However, the hepato-splanchnic circulation and oxygenation cannot be easily evaluated in the clinical setting of HD therapy. We included 185 HD patients and 15 healthy volunteers as the control group in this study. Before HD, hepatic regional oxygen saturation (rSO.sub.2 ), a marker of hepatic oxygenation reflecting the hepato-splanchnic circulation and oxygenation, was monitored using an INVOS 5100c oxygen saturation monitor. Hepatic rSO.sub.2 was significantly lower in patients undergoing HD than in healthy controls (56.4 ± 14.9% vs. 76.2 ± 9.6%, p < 0.001). Multivariable regression analysis showed that hepatic rSO.sub.2 was independently associated with body mass index (BMI; standardized coefficient: 0.294), hemoglobin (Hb) level (standardized coefficient: 0.294), a history of cardiovascular disease (standardized coefficient: -0.157), mean blood pressure (BP; standardized coefficient: 0.154), and serum albumin concentration (standardized coefficient: 0.150) in Model 1 via a simple linear regression analysis. In Model 2 using the colloid osmotic pressure (COP) in place of serum albumin concentration, the COP (standardized coefficient: 0.134) was also identified as affecting hepatic rSO.sub.2 . Basal hepatic oxygenation before HD might be affected by BMI, Hb levels, a history of cardiovascular disease, mean BP, serum albumin concentration, and the COP. Further prospective studies are needed to clarify whether changes in these parameters, including during HD, affect the hepato-splanchnic circulation and oxygenation in HD patients.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0259064