Association between the degree of obstructive sleep apnea and the severity of COVID-19: An explorative retrospective cross-sectional study

Obstructive sleep apnea (OSA) on its own, as well as its risk factors, have been found to be associated with the outcome of Coronavirus disease 2019 (COVID-19). However, the association between the degree of OSA and COVID-19 severity is unclear. Therefore, the aim of the study was to evaluate whethe...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2021-09, Vol.16 (9), p.e0257483
Main Authors: Ho, J. P. T. F, Donders, H. C. M, Zhou, N, Schipper, K, Su, N, de Lange, J
Format: Article
Language:English
Subjects:
Apnea
Cardiovascular disease
Care and treatment
Complications and side effects
Coronaviruses
COVID-19
Cross-sectional studies
Desaturation
Diagnosis
Evaluation
Health risks
Independent variables
Intubation
Measurement
Mechanical ventilation
Medical records
Medicine and Health Sciences
Oxygen
Oxyhemoglobin
Parameters
Patients
Physical Sciences
Regression analysis
Research and Analysis Methods
Risk analysis
Risk factors
Sleep
Sleep apnea
Sleep apnea syndromes
Sleep disorders
Ventilation
Viral diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Obstructive sleep apnea (OSA) on its own, as well as its risk factors, have been found to be associated with the outcome of Coronavirus disease 2019 (COVID-19). However, the association between the degree of OSA and COVID-19 severity is unclear. Therefore, the aim of the study was to evaluate whether or not parameters to clinically evaluate OSA severity and the type of OSA treatment are associated with COVID-19 severity. Patient data from OSA patients diagnosed with COVID-19 were reviewed from outpatients from the Isala Hospital and patients admitted to the Isala Hospital, starting from March until December 2020. Baseline patient data, sleep study parameters, OSA treatment information and hospital admission data were collected. Apnea hypopnea index (AHI), low oxyhemoglobin desaturation (LSAT), oxygen desaturation index (ODI), respiratory disturbance index (RDI), and the type of OSA treatment were regarded as the independent variables. COVID-19 severity–based on hospital or intensive care unit (ICU) admission, the number of days of hospitalization, and number of intubation and mechanical ventilation days–were regarded as the outcome variables. Multinomial regression analysis, binary logistic regression analysis, and zero-inflated negative binomial regression analysis were used to assess the association between the parameters to clinically evaluate OSA severity and COVID-19 severity. A total of 137 patients were included. Only LSAT was found to be significantly associated with the COVID-19 severity (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0257483