Elevated plasma levels of NT-proBNP in ambulatory patients with peripheral arterial disease

N-terminal pro B-type natriuretic peptide (NT-proBNP), a cardiac disease biomarker, has been demonstrated to be a strong independent predictor of cardiovascular events in patients without heart failure. Patients with peripheral arterial disease (PAD) are at high risk of cardiovascular events and dea...

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Bibliographic Details
Published in:PloS one 2021-07, Vol.16 (7), p.e0253792-e0253792
Main Authors: Alsuwailem, Bader, Zamzam, Abdelrahman, Syed, Muzammil H, Greco, Elisa, Wheatcroft, Mark, de Mestral, Charles, Al-Omran, Mohammed, Harlock, John, Eikelboom, John, Singh, Krishna K, Abdin, Rawand, Qadura, Mohammad
Format: Article
Language:English
Subjects:
Ambulatory care
Biology and Life Sciences
Biomarkers
Brain natriuretic peptide
Cardiovascular disease
Cardiovascular diseases
Congestive heart failure
Coronary artery disease
Coronary vessels
Correlation
Correlation analysis
Diabetes
Diabetes mellitus
Diagnosis
Genetic aspects
Health risks
Heart failure
Hospitals
Hypercholesterolemia
Hypertension
Kidney diseases
Medical prognosis
Medicine and Health Sciences
Mortality
Patients
Peptides
Peripheral vascular diseases
Plasma
Plasma levels
Regression analysis
Risk factors
Signs and symptoms
Subgroups
Vascular surgery
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Summary:N-terminal pro B-type natriuretic peptide (NT-proBNP), a cardiac disease biomarker, has been demonstrated to be a strong independent predictor of cardiovascular events in patients without heart failure. Patients with peripheral arterial disease (PAD) are at high risk of cardiovascular events and death. In this study, we investigated levels of NT-proBNP in patients with PAD compared to non-PAD controls. A total of 355 patients were recruited from outpatient clinics at a tertiary care hospital network. Plasma NT-proBNP levels were quantified using protein multiplex. There were 279 patients with both clinical and diagnostic features of PAD and 76 control patients without PAD (non-PAD cohort). Compared with non-PAD patients, median (IQR) NT-proBNP levels in PAD patients were significantly higher (225 ng/L (120-363) vs 285 ng/L (188-425), p- value = 0.001, respectively). Regression analysis demonstrated that NT-proBNP remained significantly higher in patients with PAD relative to non-PAD despite adjusting for age, sex, hypercholesterolemia, smoking and hypertension [odds ratio = 1.28 (1.07-1.54), p-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0253792