Epidermal growth factor as a potential prognostic and predictive biomarker of response to platinum-based chemotherapy

In this study, we investigated serum epidermal growth factor (EGF) in an oncological population of head- and neck and pulmonary neoplasms and whether serum EGF could serve as a prognostic marker of survival and as a predictive marker for treatment response to platinum-based chemotherapy. A total of...

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Published in:PloS one 2021-06, Vol.16 (6), p.e0252646-e0252646
Main Authors: Geens, Margot, Stappers, Sofie, Konings, Heleen, De Winter, Benedicte Y, Specenier, Pol, Van Meerbeeck, Jan P, Verpooten, Gert A, Abrams, Steven, Janssens, Annelies, Peeters, Marc, Van de Heyning, Paul, Vanderveken, Olivier M, Ledeganck, Kristien J
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Language:eng
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Summary:In this study, we investigated serum epidermal growth factor (EGF) in an oncological population of head- and neck and pulmonary neoplasms and whether serum EGF could serve as a prognostic marker of survival and as a predictive marker for treatment response to platinum-based chemotherapy. A total of 59 oncological patients and a control group of age- and sex-matched healthy volunteers were included in this study. Pre-treatment serum EGF from both groups was determined. Patient's and tumour characteristics and mortality were recorded during a 5-year follow up period. Baseline serum EGF significantly differed between the oncological patients and the healthy volunteers (p
ISSN:1932-6203
1932-6203