Ocular biometric parameters changes and choroidal vascular abnormalities in patients with neurofibromatosis type 1 evaluated by OCT-A

To analyze ocular biometric parameters alterations of the posterior pole and choroidal abnormalities in patients with neurofibromatosis type 1 (NF1) by adopting multimodal imaging, especially focusing on the role of novel diagnostic devices like swept-source optical coherence tomography angiography...

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Bibliographic Details
Published in:PloS one 2021-05, Vol.16 (5), p.e0251098-e0251098
Main Authors: Vagge, Aldo, Corazza, Paolo, Ferro Desideri, Lorenzo, Camicione, Paola, Agosto, Giulia, Vagge, Roberta, Maria Grazia, Calevo, Carnevali, Adriano, Giannaccare, Giuseppe, Nicolò, Massimo, Traverso, Carlo Enrico
Format: Article
Language:English
Subjects:
Abnormalities
Acuity
Biology and Life Sciences
Biometrics
Bone dysplasia
Brain cancer
Children
Childrens health
Choroid
Complications and side effects
Congenital diseases
Criteria
Data analysis
Diagnosis
Disease
Dysplasia
Editing
Epidemiology
Eye
Eye diseases
Genetic disorders
Genetics
Glaucoma
Glioma
Intraocular pressure
Lenses
Maternal & child health
Medical imaging
Medicine and Health Sciences
Methodology
Nervous system
Neurofibromatosis
Neurological disorders
Neurosciences
Nodules
Opacity
Ophthalmology
Patients
Recklinghausen's disease
Rehabilitation
Research and Analysis Methods
Signal transduction
Skeleton
Tumors
Uveitis
Visual acuity
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Summary:To analyze ocular biometric parameters alterations of the posterior pole and choroidal abnormalities in patients with neurofibromatosis type 1 (NF1) by adopting multimodal imaging, especially focusing on the role of novel diagnostic devices like swept-source optical coherence tomography angiography (SS-OCTA). In this prospective, case-controlled study, patients with NF1 and age-matched control subjects were quantitatively analyzed by using multimodal imaging. All the subjects underwent confocal scanning laser ophthalmoscopy (SLO), SS-OCT and SS-OCTA examinations. SS-OCT analysis revealed a lower macular retinal nerve fiber layer (RNFL) thickness in patients with NF1 compared with those with suspected NF1 (95.0±15.9 vs 109.7±11.3 μm; P = 0.001) and control subjects (106.8±14.4 μm, P = 0.003). Retinal thickness was significantly lower in NF1 patients compared to those with suspected NF1 (280.7±23.0 vs 304.2±15.3 μm; P < 0.001) and control subjects (298.7±23.8 μm, P = 0.003). The mean vascular flow area of the SCP was significantly higher in patients with NF1 (42.6±2.2%) and suspected NF1 (43.1±2.5%) compared to control subjects (41.0±2.0%; respectively, P = 0.017 and P = 0.002). In the second choroidal layer, the flow area was significantly lower in patients with NF1 compared to control subjects (45.4±4.8 vs 49.0±4.0%,; P = 0.011). Retinal thicknesses alterations and choroidal nodules are described as ocular manifestations in patients with NF1. In addition, OCTA could represent an important novel advanced imaging technique, capable of detecting early altered retinal and choroidal vascular flow area in patients with NF1.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0251098