Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage

Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage

Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the infl...

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Published in:PloS one 2021-02, Vol.16 (2), p.e0247049-e0247049
Main Authors: Hillaert, Amber, Liu, Daisy J X, Daminet, Sylvie, Broeckx, Bart J G, Stock, Emmelie, Paepe, Dominique, Hesta, Myriam, Vanderperren, Katrien
Format: Article
Language:eng
Subjects:
Adipose tissues
Animals
Biological markers
Biology and Life Sciences
Body composition
Body fat
Body weight
Chronic illnesses
Diagnosis
Diseases
Dogs
Domestic animals
Editing
Funding
Genetics
Glomerular filtration rate
Health aspects
Kidney diseases
Measurement
Medical imaging
Medicine
Medicine and Health Sciences
Methodology
Nutrition
Nutrition research
Obesity
Orthopedics
Renal function
Reviews
Risk factors
Veterinary medicine
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recordid cdi_plos_journals_2490578130
title Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage
format Article
creator Hillaert, Amber
Liu, Daisy J X
Daminet, Sylvie
Broeckx, Bart J G
Stock, Emmelie
Paepe, Dominique
Hesta, Myriam
Vanderperren, Katrien
subjects Adipose tissues
Animals
Biological markers
Biology and Life Sciences
Body composition
Body fat
Body weight
Chronic illnesses
Diagnosis
Diseases
Dogs
Domestic animals
Editing
Funding
Genetics
Glomerular filtration rate
Health aspects
Kidney diseases
Measurement
Medical imaging
Medicine
Medicine and Health Sciences
Methodology
Nutrition
Nutrition research
Obesity
Orthopedics
Renal function
Reviews
Risk factors
Veterinary medicine
ispartof PloS one, 2021-02, Vol.16 (2), p.e0247049-e0247049
description Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the influence of an increased body fat percentage on the level of SDMA. Sixteen lean Beagles were randomly assigned to the control group or weight-change group in age- and gender-matched pairs. The energy intake of the control group (n = 8) was strictly regulated to maintain an ideal body weight for 83 weeks, while the weight-change group (n = 8) was fed to induce weight gain (week 0-47), to maintain stable excessive body weight (week 47-56) and to lose weight (week 56-83), consecutively. At 8 specified time points, the body condition score, body composition, glomerular filtration rate, serum concentration of SDMA and creatinine were analyzed. In the control group, the within-subject coefficient of variation, between-subject coefficient of variation, reference change value (type I error = 5%) and index of individuality were 0.16, 0.22, 0.43 and 0.73, respectively. The control group and weight-change group did not differ significantly in SDMA concentration. SDMA showed a significant negative association (coefficient = -0.07) with body fat percentage (p
language eng
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The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the influence of an increased body fat percentage on the level of SDMA. Sixteen lean Beagles were randomly assigned to the control group or weight-change group in age- and gender-matched pairs. The energy intake of the control group (n = 8) was strictly regulated to maintain an ideal body weight for 83 weeks, while the weight-change group (n = 8) was fed to induce weight gain (week 0-47), to maintain stable excessive body weight (week 47-56) and to lose weight (week 56-83), consecutively. At 8 specified time points, the body condition score, body composition, glomerular filtration rate, serum concentration of SDMA and creatinine were analyzed. In the control group, the within-subject coefficient of variation, between-subject coefficient of variation, reference change value (type I error = 5%) and index of individuality were 0.16, 0.22, 0.43 and 0.73, respectively. The control group and weight-change group did not differ significantly in SDMA concentration. SDMA showed a significant negative association (coefficient = -0.07) with body fat percentage (p&lt;0.01) in the weight-change group and a significant positive association (coefficient = 7.79) with serum creatinine (p&lt;0.01) in the entire study population. In conclusion, SDMA concentration has high long-term stability in healthy adult dogs. For the evaluation of SDMA concentrations, subject-specific reference values are preferred over a population-based reference value seen their higher sensitivity. 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This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillaert, Amber</au><au>Liu, Daisy J X</au><au>Daminet, Sylvie</au><au>Broeckx, Bart J G</au><au>Stock, Emmelie</au><au>Paepe, Dominique</au><au>Hesta, Myriam</au><au>Vanderperren, Katrien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2021-02-17</date><risdate>2021</risdate><volume>16</volume><issue>2</issue><spage>e0247049</spage><epage>e0247049</epage><pages>e0247049-e0247049</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Competing Interests: The authors declare the following competing financial interests: SDMA analyses were financially supported and performed by IDEXX Laboratories, Inc.. The diet used in this study and blood and urine analyses were financially supported by Virbac. This does not alter our adherence to PLOS ONE policies on sharing data and materials.</notes><notes>These authors also contributed equally to this work.</notes><abstract>Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the influence of an increased body fat percentage on the level of SDMA. Sixteen lean Beagles were randomly assigned to the control group or weight-change group in age- and gender-matched pairs. The energy intake of the control group (n = 8) was strictly regulated to maintain an ideal body weight for 83 weeks, while the weight-change group (n = 8) was fed to induce weight gain (week 0-47), to maintain stable excessive body weight (week 47-56) and to lose weight (week 56-83), consecutively. At 8 specified time points, the body condition score, body composition, glomerular filtration rate, serum concentration of SDMA and creatinine were analyzed. In the control group, the within-subject coefficient of variation, between-subject coefficient of variation, reference change value (type I error = 5%) and index of individuality were 0.16, 0.22, 0.43 and 0.73, respectively. The control group and weight-change group did not differ significantly in SDMA concentration. SDMA showed a significant negative association (coefficient = -0.07) with body fat percentage (p&lt;0.01) in the weight-change group and a significant positive association (coefficient = 7.79) with serum creatinine (p&lt;0.01) in the entire study population. In conclusion, SDMA concentration has high long-term stability in healthy adult dogs. For the evaluation of SDMA concentrations, subject-specific reference values are preferred over a population-based reference value seen their higher sensitivity. Moreover, an increased body fat percentage does seem to affect the serum SDMA concentration of otherwise healthy dogs, but its clinical relevance has to be clarified in further research.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>33596230</pmid><doi>10.1371/journal.pone.0247049</doi><tpages>e0247049</tpages><orcidid>https://orcid.org/0000-0003-3262-8495</orcidid><oa>free_for_read</oa></addata></record>