Serum symmetric dimethylarginine shows a relatively consistent long-term concentration in healthy dogs with a significant effect of increased body fat percentage

Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the infl...

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Published in:	PloS one 2021-02, Vol.16 (2), p.e0247049-e0247049
Main Authors:	Hillaert, Amber, Liu, Daisy J X, Daminet, Sylvie, Broeckx, Bart J G, Stock, Emmelie, Paepe, Dominique, Hesta, Myriam, Vanderperren, Katrien
Format:	Article
Language:	eng
Subjects:	Adipose tissues Animals Biological markers Biology and Life Sciences Body composition Body fat Body weight Chronic illnesses Diagnosis Diseases Dogs Domestic animals Editing Funding Genetics Glomerular filtration rate Health aspects Kidney diseases Measurement Medical imaging Medicine Medicine and Health Sciences Methodology Nutrition Nutrition research Obesity Orthopedics Renal function Reviews Risk factors Veterinary medicine
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Summary:	Symmetric dimethylarginine (SDMA) is a promising renal marker that correlates well with the glomerular filtration rate and could allow earlier detection of impaired renal function. The main objectives of this study were to assess the long-term variability of SDMA in healthy dogs and examine the influence of an increased body fat percentage on the level of SDMA. Sixteen lean Beagles were randomly assigned to the control group or weight-change group in age- and gender-matched pairs. The energy intake of the control group (n = 8) was strictly regulated to maintain an ideal body weight for 83 weeks, while the weight-change group (n = 8) was fed to induce weight gain (week 0-47), to maintain stable excessive body weight (week 47-56) and to lose weight (week 56-83), consecutively. At 8 specified time points, the body condition score, body composition, glomerular filtration rate, serum concentration of SDMA and creatinine were analyzed. In the control group, the within-subject coefficient of variation, between-subject coefficient of variation, reference change value (type I error = 5%) and index of individuality were 0.16, 0.22, 0.43 and 0.73, respectively. The control group and weight-change group did not differ significantly in SDMA concentration. SDMA showed a significant negative association (coefficient = -0.07) with body fat percentage (p
ISSN:	1932-6203 1932-6203