Comprehensive live-cell imaging analysis of cryptotanshinone and synergistic drug-screening effects in various human and canine cancer cell lines

Several studies have highlighted both the extreme anticancer effects of Cryptotanshinone (CT), a Stat3 crippling component from Salvia miltiorrhiza, as well as other STAT3 inhibitors to fight cancer. Data presented in this experiment incorporates 2 years of in vitro studies applying a comprehensive...

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Bibliographic Details
Published in:PloS one 2021-02, Vol.16 (2), p.e0236074-e0236074
Main Authors: Bittner, Michael L, Lopes, Rosana, Hua, Jianping, Sima, Chao, Datta, Aniruddha, Wilson-Robles, Heather
Format: Article
Language:English
Subjects:
Apoptosis
Bioinformatics
Biology and Life Sciences
Biomedical materials
Biotechnology
Bone cancer
Breast cancer
Cancer
Cancer cells
Cancer therapies
Cell cycle
Cell death
Chemotherapy
Computed tomography
Cryptotanshinone
Cyclin D1
D1 protein
Disease
Dogs
Drugs
Engineering
Epidemiology
Experimental methods
Experiments
Gelatinase A
Gelatinase B
Gene expression
Genetic aspects
Genomics
Health aspects
Health care
In vivo methods and tests
Kinases
Matrix metalloproteinases
Medical prognosis
Medicine
Medicine and Health Sciences
Melanoma
Metabolism
Metastases
Mutation
Osteosarcoma
Pancreas
Pancreatic cancer
Phosphorylation
Prostate
Prostate cancer
Proteins
Rapamycin
Sage
Sarcoma
Skin cancer
Testing
TOR protein
Tumor cell lines
Tumors
Veterinary medicine
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Summary:Several studies have highlighted both the extreme anticancer effects of Cryptotanshinone (CT), a Stat3 crippling component from Salvia miltiorrhiza, as well as other STAT3 inhibitors to fight cancer. Data presented in this experiment incorporates 2 years of in vitro studies applying a comprehensive live-cell drug-screening analysis of human and canine cancer cells exposed to CT at 20 μM concentration, as well as to other drug combinations. As previously observed in other studies, dogs are natural cancer models, given to their similarity in cancer genetics, epidemiology and disease progression compared to humans. Results obtained from several types of human and canine cancer cells exposed to CT and varied drug combinations, verified CT efficacy at combating cancer by achieving an extremely high percentage of apoptosis within 24 hours of drug exposure. CT anticancer efficacy in various human and canine cancer cell lines denotes its ability to interact across different biological processes and cancer regulatory cell networks, driving inhibition of cancer cell survival.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0236074