ACE2 polymorphisms as potential players in COVID-19 outcome

The clinical condition COVID-19, caused by SARS-CoV-2, was declared a pandemic by the WHO in March 2020. Currently, there are more than 5 million cases worldwide, and the pandemic has increased exponentially in many countries, with different incidences and death rates among regions/ethnicities and,...

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Bibliographic Details
Published in:PloS one 2020-12, Vol.15 (12), p.e0243887
Main Authors: Khayat, André Salim, de Assumpção, Paulo Pimentel, Meireles Khayat, Bruna Claudia, Thomaz Araújo, Taíssa Maíra, Batista-Gomes, Jéssica Almeida, Imbiriba, Luciana Carvalho, Ishak, Geraldo, de Assumpção, Paula Baraúna, Moreira, Fabiano Cordeiro, Burbano, Rommel Rodriguez, Ribeiro-Dos-Santos, André, Ribeiro-Dos-Santos, Ândrea Kelly, Dos Santos, Ney Pereira Carneiro, Dos Santos, Sidney Emmanuel Batista
Format: Article
Language:English
Subjects:
ACE2
Angiotensin
Angiotensin converting enzyme
Angiotensin I
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2 - genetics
Biology and Life Sciences
Coronaviruses
COVID-19
COVID-19 - genetics
COVID-19 - virology
Digital archives
Disease transmission
Enzymes
Epidemiology
Exome - genetics
Female
Genealogy
Genetic aspects
Genetic diversity
Genetic engineering
Genetic polymorphisms
Genomes
Health aspects
Humans
Infections
Male
Medicine and Health Sciences
Minority & ethnic groups
Native North Americans
Open Reading Frames - genetics
Pandemics
People and places
Peptidyl-dipeptidase A
Physiological aspects
Polymorphism, Single Nucleotide - genetics
Population
Populations
Regulatory Sequences, Ribonucleic Acid - genetics
RNA, Untranslated - genetics
Severe acute respiratory syndrome coronavirus 2
South America
Viral diseases
Viral infections
X chromosomes
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Summary:The clinical condition COVID-19, caused by SARS-CoV-2, was declared a pandemic by the WHO in March 2020. Currently, there are more than 5 million cases worldwide, and the pandemic has increased exponentially in many countries, with different incidences and death rates among regions/ethnicities and, intriguingly, between sexes. In addition to the many factors that can influence these discrepancies, we suggest a biological aspect, the genetic variation at the viral S protein receptor in human cells, ACE2 (angiotensin I-converting enzyme 2), which may contribute to the worse clinical outcome in males and in some regions worldwide. We performed exomics analysis in native and admixed South American populations, and we also conducted in silico genomics databank investigations in populations from other continents. Interestingly, at least ten polymorphisms in coding, noncoding and regulatory sites were found that can shed light on this issue and offer a plausible biological explanation for these epidemiological differences. In conclusion, there are ACE2 polymorphisms that could influence epidemiological discrepancies observed among ancestry and, moreover, between sexes.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0243887