Pre-test probability for SARS-Cov-2-related infection score: The PARIS score

In numerous countries, large population testing is impossible due to the limited availability of RT-PCR kits and CT-scans. This study aimed to determine a pre-test probability score for SARS-CoV-2 infection. This multicenter retrospective study (4 University Hospitals) included patients with clinica...

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Bibliographic Details
Published in:	PloS one 2020-12, Vol.15 (12), p.e0243342-e0243342
Main Authors:	Tordjman, Mickael, Mekki, Ahmed, Mali, Rahul D, Saab, Ines, Chassagnon, Guillaume, Guillo, Enora, Burns, Robert, Eshagh, Deborah, Beaune, Sebastien, Madelin, Guillaume, Bessis, Simon, Feydy, Antoine, Mihoubi, Fadila, Doumenc, Benoit, Mouthon, Luc, Carlier, Robert-Yves, Drapé, Jean-Luc, Revel, Marie-Pierre
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Asymptomatic Biology and life sciences Blood Chronic obstructive pulmonary disease Computed tomography Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 - genetics Electrolytes Female Hospitals Humans Independent variables Infections Infectious diseases Internal medicine Leukocytes (eosinophilic) Lymphocytes Male Medical imaging Medicine Medicine and health sciences Middle Aged Multivariate analysis Patients Pneumonia Polymerase chain reaction Probability Radiology Reagent Kits, Diagnostic Research and Analysis Methods Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 - genetics Sensitivity and Specificity Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Statistical analysis Viral diseases White blood cells
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Summary:	In numerous countries, large population testing is impossible due to the limited availability of RT-PCR kits and CT-scans. This study aimed to determine a pre-test probability score for SARS-CoV-2 infection. This multicenter retrospective study (4 University Hospitals) included patients with clinical suspicion of SARS-CoV-2 infection. Demographic characteristics, clinical symptoms, and results of blood tests (complete white blood cell count, serum electrolytes and CRP) were collected. A pre-test probability score was derived from univariate analyses of clinical and biological variables between patients and controls, followed by multivariate binary logistic analysis to determine the independent variables associated with SARS-CoV-2 infection. 605 patients were included between March 10th and April 30th, 2020 (200 patients for the training cohort, 405 consecutive patients for the validation cohort). In the multivariate analysis, lymphocyte (
ISSN:	1932-6203 1932-6203