Current status of proton pump inhibitor use in Japanese elderly patients with non-valvular atrial fibrillation: A subanalysis of the ANAFIE Registry

The real-world status of proton pump inhibitor (PPI) use in patients with atrial fibrillation (AF) receiving antithrombotic treatment is largely unknown. The All Nippon AF In the Elderly (ANAFIE) Registry, a prospective, multicenter, observational study, aimed to determine treatment patterns, risk f...

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Published in:PloS one 2020-11, Vol.15 (11), p.e0240859
Main Authors: Mizokami, Yuji, Yamamoto, Takatsugu, Atarashi, Hirotsugu, Yamashita, Takeshi, Akao, Masaharu, Ikeda, Takanori, Koretsune, Yukihiro, Okumura, Ken, Shimizu, Wataru, Tsutsui, Hiroyuki, Toyoda, Kazunori, Hirayama, Atsushi, Yasaka, Masahiro, Yamaguchi, Takenori, Teramukai, Satoshi, Kimura, Tetsuya, Kaburagi, Jumpei, Takita, Atsushi, Inoue, Hiroshi
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anticoagulants
Anticoagulants - administration & dosage
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Antiplatelet therapy
Atrial fibrillation
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Biology and Life Sciences
Bleeding
Cardiac arrhythmia
Cohort Studies
Complications and side effects
Drug therapy
Drug Therapy, Combination
Drugs
Elderly patients
Esophagitis
Female
Fibrillation
Fibrinolytic agents
Gastrointestinal hemorrhage
Health risks
Hemorrhage - epidemiology
Hemorrhage - etiology
Hemorrhage - prevention & control
Hospitals
Humans
Inhibitors
Japan - epidemiology
Male
Medicine and Health Sciences
Mortality
Older people
Patients
Platelet Aggregation Inhibitors - administration & dosage
Platelet Aggregation Inhibitors - adverse effects
Platelet Aggregation Inhibitors - therapeutic use
Prevention
Prospective Studies
Proton pump inhibitors
Proton Pump Inhibitors - administration & dosage
Proton Pump Inhibitors - therapeutic use
Protons
Registries
Risk analysis
Risk Factors
Standard deviation
Stroke
Stroke - epidemiology
Stroke - etiology
Stroke - prevention & control
Warfarin
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Summary:The real-world status of proton pump inhibitor (PPI) use in patients with atrial fibrillation (AF) receiving antithrombotic treatment is largely unknown. The All Nippon AF In the Elderly (ANAFIE) Registry, a prospective, multicenter, observational study, aimed to determine treatment patterns, risk factors, and outcomes among elderly (aged ≥75 years) Japanese non-valvular AF (NVAF) patients in the real-world clinical setting. The present subanalysis of the ANAFIE Registry determined the PPI prescription status of 32,490 elderly Japanese NVAF patients. Patients were stratified by PPI use (PPI+) or no PPI use (PPI-). Risk scores for stroke (CHADS2, CHA2DS2-VASc) and bleeding (HAS-BLED), anticoagulant use, time in therapeutic range (TTR) for warfarin, and anticoagulant/antiplatelet combination use were evaluated. PPIs were used in 11,981 (36.9%) patients. Compared with the PPI- group, the PPI+ group included a greater proportion of female patients (45.2% vs 41.3%; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0240859