Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2

Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2...

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Bibliographic Details
Published in:PloS one 2020-10, Vol.15 (10), p.e0241471-e0241471
Main Authors: Kandeil, Ahmed, Gomaa, Mokhtar R, El Taweel, Ahmed, Mostafa, Ahmed, Shehata, Mahmoud, Kayed, Ahmed E, Kutkat, Omnia, Moatasim, Yassmin, Mahmoud, Sara H, Kamel, Mina Nabil, Shama, Noura M Abo, El Sayes, Mohamed, El-Shesheny, Rabeh, Yassien, Mahmoud A, Webby, Richard J, Kayali, Ghazi, Ali, Mohamed A
Format: Article
Language:English
Subjects:
Adaptive immunity
Adolescent
Adult
Aged
Animals
Antibodies
Antibodies, Neutralizing - biosynthesis
Antibodies, Neutralizing - blood
Antibodies, Viral - biosynthesis
Antibodies, Viral - blood
Antibody response
Bacillus Calmette-Guerin vaccine
BCG
Betacoronavirus - immunology
Child
Child, Preschool
Children
Coronavirus Infections - immunology
Coronavirus Infections - prevention & control
Coronaviruses
COVID-19
Cross Reactions
Diphtheria
Drug dosages
Female
Hepatitis
Hepatitis B
Hepatitis B virus
Humans
Immune response
Immune Sera - immunology
Immunogenicity, Vaccine
Measles
Mice
Mice, Inbred BALB C
Middle Aged
Mumps
Neutralization Tests
Neutralizing
Observations
Pandemics - prevention & control
Patient outcomes
Pertussis
Physiological research
Pneumonia, Viral - immunology
Pneumonia, Viral - prevention & control
Prevention
Public health
Rotavirus
Rubella
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Tetanus
Vaccination
Vaccines
Vaccines - immunology
Vaccines, Inactivated - immunology
Viral diseases
Viral Vaccines - immunology
Viruses
Young Adult
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Summary:Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2 infection through trained or adaptive immune responses. Here, we tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated that none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post vaccination. We conclude that if such vaccines have any role in COVID-19 immunity, this role is not antibody-mediated.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0241471