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COVID-19 and acute juvenile paracoccidioidomycosis coinfection
Case presentation A 19-year-old male patient was admitted to the Evandro Chagas National Institute of Infectious Diseases, Fiocruz, on 10 March 2020 complaining of an 8-month history of progressive weight loss; multiple cervical, axillary, and inguinal lymph node enlargements; abdominal distension;...
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| Published in: | PLoS neglected tropical diseases 2020-08, Vol.14 (8), p.e0008559-e0008559 |
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| creator | de Macedo, Priscila Marques Freitas, Dayvison Francis Saraiva Varon, Andrea Gina Lamas, Cristiane da Cruz Ferreira, Livia Cristina Fonseca Freitas, Andrea d'Avila Ferreira, Marcel Treptow Nunes, Estevão Portela Siqueira, Marilda Mendonça Veloso, Valdiléa G do Valle, Antonio Carlos Francesconi |
| description | Case presentation A 19-year-old male patient was admitted to the Evandro Chagas National Institute of Infectious Diseases, Fiocruz, on 10 March 2020 complaining of an 8-month history of progressive weight loss; multiple cervical, axillary, and inguinal lymph node enlargements; abdominal distension; and disseminated cutaneous lesions (Fig 1). Ulcerated skin lesions covered by crusts on the patient’s face and scalp. https://doi.org/10.1371/journal.pntd.0008559.g001 A histopathological examination of the left inguinal lymph node revealed chronic granulomatous lymphadenitis with the presence of multiple budding fungal structures typical of Paracoccidioides spp. in silver staining. Because he presented an important left inguinal lymph node enlargement with fluctuation, its content was aspirated for relief and diagnostic confirmation. Real-time reverse-transcription PCR (RT-PCR) (Biomanguinhos kit [E+P1], Fiocruz, Brazil) of nasopharyngeal secretion and bronchoalveolar fluid tested positive for severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2). In the chronic PCM form, frequent tobacco abuse, chronic obstructive pulmonary disease, and pulmonary alterations caused by the infection lead to tissue fibrosis, justifying this increased risk. |
| doi_str_mv | 10.1371/journal.pntd.0008559 |
| format | article |
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Ulcerated skin lesions covered by crusts on the patient’s face and scalp. https://doi.org/10.1371/journal.pntd.0008559.g001 A histopathological examination of the left inguinal lymph node revealed chronic granulomatous lymphadenitis with the presence of multiple budding fungal structures typical of Paracoccidioides spp. in silver staining. Because he presented an important left inguinal lymph node enlargement with fluctuation, its content was aspirated for relief and diagnostic confirmation. Real-time reverse-transcription PCR (RT-PCR) (Biomanguinhos kit [E+P1], Fiocruz, Brazil) of nasopharyngeal secretion and bronchoalveolar fluid tested positive for severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2). In the chronic PCM form, frequent tobacco abuse, chronic obstructive pulmonary disease, and pulmonary alterations caused by the infection lead to tissue fibrosis, justifying this increased risk.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0008559</identifier><identifier>PMID: 32776930</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abuse ; Acute Disease ; Alveoli ; Ascites ; Betacoronavirus ; Biology and life sciences ; Biomarkers ; Bronchus ; Budding ; Care and treatment ; Case studies ; Catheters ; Chronic infection ; Chronic obstructive pulmonary disease ; Coinfection ; Concretions ; Coronavirus Infections - complications ; Coronavirus Infections - diagnosis ; Coronavirus Infections - transmission ; Coronaviruses ; COVID-19 ; Cross Infection - complications ; Crusts ; Diagnosis ; Diagnostic systems ; Disease transmission ; Distension ; DNA ; Enlargement ; Epidemics ; Fever ; Fibrosis ; Histopathology ; Hospitalization ; Humans ; Infectious diseases ; Lesions ; Lung diseases ; Lymph ; Lymph nodes ; Lymphadenitis ; Lymphatic system ; Male ; Medicine and Health Sciences ; Nosocomial infections ; Nucleotide sequence ; Obstructive lung disease ; Pandemics ; Paracoccidioidomycosis ; Paracoccidioidomycosis - complications ; Paracoccidioidomycosis - diagnosis ; Paracoccidioidomycosis - immunology ; Patients ; PCR ; Pleural effusion ; Pneumonia, Viral - complications ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - transmission ; Polymerase chain reaction ; Radiography, Thoracic ; SARS-CoV-2 ; Scalp ; Secretion ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Silver ; Skin ; Skin diseases ; Skin lesions ; South American blastomycosis ; Symposium ; Tobacco ; Transcription ; Tropical diseases ; Vector-borne diseases ; Viral diseases ; Weight loss ; Workers ; Young Adult</subject><ispartof>PLoS neglected tropical diseases, 2020-08, Vol.14 (8), p.e0008559-e0008559</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 de Macedo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Ulcerated skin lesions covered by crusts on the patient’s face and scalp. https://doi.org/10.1371/journal.pntd.0008559.g001 A histopathological examination of the left inguinal lymph node revealed chronic granulomatous lymphadenitis with the presence of multiple budding fungal structures typical of Paracoccidioides spp. in silver staining. Because he presented an important left inguinal lymph node enlargement with fluctuation, its content was aspirated for relief and diagnostic confirmation. Real-time reverse-transcription PCR (RT-PCR) (Biomanguinhos kit [E+P1], Fiocruz, Brazil) of nasopharyngeal secretion and bronchoalveolar fluid tested positive for severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2). In the chronic PCM form, frequent tobacco abuse, chronic obstructive pulmonary disease, and pulmonary alterations caused by the infection lead to tissue fibrosis, justifying this increased risk.</description><subject>Abuse</subject><subject>Acute Disease</subject><subject>Alveoli</subject><subject>Ascites</subject><subject>Betacoronavirus</subject><subject>Biology and life sciences</subject><subject>Biomarkers</subject><subject>Bronchus</subject><subject>Budding</subject><subject>Care and treatment</subject><subject>Case studies</subject><subject>Catheters</subject><subject>Chronic infection</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Coinfection</subject><subject>Concretions</subject><subject>Coronavirus Infections - complications</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - transmission</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cross Infection - complications</subject><subject>Crusts</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Disease transmission</subject><subject>Distension</subject><subject>DNA</subject><subject>Enlargement</subject><subject>Epidemics</subject><subject>Fever</subject><subject>Fibrosis</subject><subject>Histopathology</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lesions</subject><subject>Lung diseases</subject><subject>Lymph</subject><subject>Lymph nodes</subject><subject>Lymphadenitis</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Nosocomial infections</subject><subject>Nucleotide sequence</subject><subject>Obstructive lung disease</subject><subject>Pandemics</subject><subject>Paracoccidioidomycosis</subject><subject>Paracoccidioidomycosis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Macedo, Priscila Marques</au><au>Freitas, Dayvison Francis Saraiva</au><au>Varon, Andrea Gina</au><au>Lamas, Cristiane da Cruz</au><au>Ferreira, Livia Cristina Fonseca</au><au>Freitas, Andrea d'Avila</au><au>Ferreira, Marcel Treptow</au><au>Nunes, Estevão Portela</au><au>Siqueira, Marilda Mendonça</au><au>Veloso, Valdiléa G</au><au>do Valle, Antonio Carlos Francesconi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COVID-19 and acute juvenile paracoccidioidomycosis coinfection</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2020-08-10</date><risdate>2020</risdate><volume>14</volume><issue>8</issue><spage>e0008559</spage><epage>e0008559</epage><pages>e0008559-e0008559</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><notes>ObjectType-Case Study-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-4</notes><notes>content type line 23</notes><notes>ObjectType-Report-1</notes><notes>ObjectType-Article-3</notes><notes>The authors have declared that no competing interests exist.</notes><abstract>Case presentation A 19-year-old male patient was admitted to the Evandro Chagas National Institute of Infectious Diseases, Fiocruz, on 10 March 2020 complaining of an 8-month history of progressive weight loss; multiple cervical, axillary, and inguinal lymph node enlargements; abdominal distension; and disseminated cutaneous lesions (Fig 1). Ulcerated skin lesions covered by crusts on the patient’s face and scalp. https://doi.org/10.1371/journal.pntd.0008559.g001 A histopathological examination of the left inguinal lymph node revealed chronic granulomatous lymphadenitis with the presence of multiple budding fungal structures typical of Paracoccidioides spp. in silver staining. Because he presented an important left inguinal lymph node enlargement with fluctuation, its content was aspirated for relief and diagnostic confirmation. Real-time reverse-transcription PCR (RT-PCR) (Biomanguinhos kit [E+P1], Fiocruz, Brazil) of nasopharyngeal secretion and bronchoalveolar fluid tested positive for severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2). In the chronic PCM form, frequent tobacco abuse, chronic obstructive pulmonary disease, and pulmonary alterations caused by the infection lead to tissue fibrosis, justifying this increased risk.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32776930</pmid><doi>10.1371/journal.pntd.0008559</doi><orcidid>https://orcid.org/0000-0002-6900-9703</orcidid><orcidid>https://orcid.org/0000-0003-0054-6962</orcidid><orcidid>https://orcid.org/0000-0002-7542-2780</orcidid><orcidid>https://orcid.org/0000-0003-2039-2438</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2020-08, Vol.14 (8), p.e0008559-e0008559 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_2443590213 |
| source | Publicly Available Content Database; PubMed Central; Coronavirus Research Database |
| subjects | Abuse Acute Disease Alveoli Ascites Betacoronavirus Biology and life sciences Biomarkers Bronchus Budding Care and treatment Case studies Catheters Chronic infection Chronic obstructive pulmonary disease Coinfection Concretions Coronavirus Infections - complications Coronavirus Infections - diagnosis Coronavirus Infections - transmission Coronaviruses COVID-19 Cross Infection - complications Crusts Diagnosis Diagnostic systems Disease transmission Distension DNA Enlargement Epidemics Fever Fibrosis Histopathology Hospitalization Humans Infectious diseases Lesions Lung diseases Lymph Lymph nodes Lymphadenitis Lymphatic system Male Medicine and Health Sciences Nosocomial infections Nucleotide sequence Obstructive lung disease Pandemics Paracoccidioidomycosis Paracoccidioidomycosis - complications Paracoccidioidomycosis - diagnosis Paracoccidioidomycosis - immunology Patients PCR Pleural effusion Pneumonia, Viral - complications Pneumonia, Viral - diagnosis Pneumonia, Viral - transmission Polymerase chain reaction Radiography, Thoracic SARS-CoV-2 Scalp Secretion Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Silver Skin Skin diseases Skin lesions South American blastomycosis Symposium Tobacco Transcription Tropical diseases Vector-borne diseases Viral diseases Weight loss Workers Young Adult |
| title | COVID-19 and acute juvenile paracoccidioidomycosis coinfection |
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