COVID-19 and acute juvenile paracoccidioidomycosis coinfection

Case presentation A 19-year-old male patient was admitted to the Evandro Chagas National Institute of Infectious Diseases, Fiocruz, on 10 March 2020 complaining of an 8-month history of progressive weight loss; multiple cervical, axillary, and inguinal lymph node enlargements; abdominal distension;...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2020-08, Vol.14 (8), p.e0008559-e0008559
Main Authors: de Macedo, Priscila Marques, Freitas, Dayvison Francis Saraiva, Varon, Andrea Gina, Lamas, Cristiane da Cruz, Ferreira, Livia Cristina Fonseca, Freitas, Andrea d'Avila, Ferreira, Marcel Treptow, Nunes, Estevão Portela, Siqueira, Marilda Mendonça, Veloso, Valdiléa G, do Valle, Antonio Carlos Francesconi
Format: Article
Language:English
Subjects:
Abuse
Acute Disease
Alveoli
Ascites
Betacoronavirus
Biology and life sciences
Biomarkers
Bronchus
Budding
Care and treatment
Case studies
Catheters
Chronic infection
Chronic obstructive pulmonary disease
Coinfection
Concretions
Coronavirus Infections - complications
Coronavirus Infections - diagnosis
Coronavirus Infections - transmission
Coronaviruses
COVID-19
Cross Infection - complications
Crusts
Diagnosis
Diagnostic systems
Disease transmission
Distension
DNA
Enlargement
Epidemics
Fever
Fibrosis
Histopathology
Hospitalization
Humans
Infectious diseases
Lesions
Lung diseases
Lymph
Lymph nodes
Lymphadenitis
Lymphatic system
Male
Medicine and Health Sciences
Nosocomial infections
Nucleotide sequence
Obstructive lung disease
Pandemics
Paracoccidioidomycosis
Paracoccidioidomycosis - complications
Paracoccidioidomycosis - diagnosis
Paracoccidioidomycosis - immunology
Patients
PCR
Pleural effusion
Pneumonia, Viral - complications
Pneumonia, Viral - diagnosis
Pneumonia, Viral - transmission
Polymerase chain reaction
Radiography, Thoracic
SARS-CoV-2
Scalp
Secretion
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Silver
Skin
Skin diseases
Skin lesions
South American blastomycosis
Symposium
Tobacco
Transcription
Tropical diseases
Vector-borne diseases
Viral diseases
Weight loss
Workers
Young Adult
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Summary:Case presentation A 19-year-old male patient was admitted to the Evandro Chagas National Institute of Infectious Diseases, Fiocruz, on 10 March 2020 complaining of an 8-month history of progressive weight loss; multiple cervical, axillary, and inguinal lymph node enlargements; abdominal distension; and disseminated cutaneous lesions (Fig 1). Ulcerated skin lesions covered by crusts on the patient’s face and scalp. https://doi.org/10.1371/journal.pntd.0008559.g001 A histopathological examination of the left inguinal lymph node revealed chronic granulomatous lymphadenitis with the presence of multiple budding fungal structures typical of Paracoccidioides spp. in silver staining. Because he presented an important left inguinal lymph node enlargement with fluctuation, its content was aspirated for relief and diagnostic confirmation. Real-time reverse-transcription PCR (RT-PCR) (Biomanguinhos kit [E+P1], Fiocruz, Brazil) of nasopharyngeal secretion and bronchoalveolar fluid tested positive for severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2). In the chronic PCM form, frequent tobacco abuse, chronic obstructive pulmonary disease, and pulmonary alterations caused by the infection lead to tissue fibrosis, justifying this increased risk.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0008559